Xiaohang Zhang, Wenze Wu, Guisheng Zhou, Xi Huang, Min Xu, Qiulong Zhao, Hui Yan
{"title":"酒精使用与创伤性脑损伤的关系：来自孟德尔随机化的证据","authors":"Xiaohang Zhang, Wenze Wu, Guisheng Zhou, Xi Huang, Min Xu, Qiulong Zhao, Hui Yan","doi":"10.1080/02699052.2025.2460740","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Observational studies suggest that alcohol consumption increases the risk of traumatic brain injury (TBI); however, the causality of this association remains unclear.</p><p><strong>Objectives: </strong>This study aimed to identify which drinking pattern is the primary factor influencing TBI.</p><p><strong>Method: </strong>Two-sample Mendelian randomization (MR) was used to assess whether drinking patterns (alcohol consumption, abuse, and intake frequency) are causally associated with TBI risk.</p><p><strong>Results: </strong>MR analysis revealed causal effects of alcohol intake frequency [odds ratio (OR) 0.806, 95% confidence interval (CI): 0.665-0.978, <i>p</i> = 0.028, beta: -0.215, se: 0.098], alcohol drinks per week (OR 1.772, 95% CI: 1.140-2.753, <i>p</i> = 0.011, beta: 0.572, se: 0.225), and alcohol abuse (OR 1.095, 95% CI: 1.006-1.192, <i>p</i> = 0.035, beta: 0.091, se: 0.043) on TBI. Additionally, no causal effect of alcohol consumption (OR 0.730, 95% CI: 0.264-2.025, <i>p</i> = 0.546, beta: -0.314, se: 0.520) or average monthly alcohol intake (OR 1.138, 95% CI: 0.805-1.609, <i>p</i> = 0.463, beta: 0.130, se: 0.177) on TBI was observed. Similarly, the effects of TBI on alcohol intake were statistically non-significant.</p><p><strong>Conclusion: </strong>Drinking patterns, including alcohol intake frequency and abuse, influence TBI, whereas TBI rarely influences drinking patterns.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"610-617"},"PeriodicalIF":1.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between alcohol use and traumatic brain injury: evidence from Mendelian randomization.\",\"authors\":\"Xiaohang Zhang, Wenze Wu, Guisheng Zhou, Xi Huang, Min Xu, Qiulong Zhao, Hui Yan\",\"doi\":\"10.1080/02699052.2025.2460740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Observational studies suggest that alcohol consumption increases the risk of traumatic brain injury (TBI); however, the causality of this association remains unclear.</p><p><strong>Objectives: </strong>This study aimed to identify which drinking pattern is the primary factor influencing TBI.</p><p><strong>Method: </strong>Two-sample Mendelian randomization (MR) was used to assess whether drinking patterns (alcohol consumption, abuse, and intake frequency) are causally associated with TBI risk.</p><p><strong>Results: </strong>MR analysis revealed causal effects of alcohol intake frequency [odds ratio (OR) 0.806, 95% confidence interval (CI): 0.665-0.978, <i>p</i> = 0.028, beta: -0.215, se: 0.098], alcohol drinks per week (OR 1.772, 95% CI: 1.140-2.753, <i>p</i> = 0.011, beta: 0.572, se: 0.225), and alcohol abuse (OR 1.095, 95% CI: 1.006-1.192, <i>p</i> = 0.035, beta: 0.091, se: 0.043) on TBI. Additionally, no causal effect of alcohol consumption (OR 0.730, 95% CI: 0.264-2.025, <i>p</i> = 0.546, beta: -0.314, se: 0.520) or average monthly alcohol intake (OR 1.138, 95% CI: 0.805-1.609, <i>p</i> = 0.463, beta: 0.130, se: 0.177) on TBI was observed. Similarly, the effects of TBI on alcohol intake were statistically non-significant.</p><p><strong>Conclusion: </strong>Drinking patterns, including alcohol intake frequency and abuse, influence TBI, whereas TBI rarely influences drinking patterns.</p>\",\"PeriodicalId\":9082,\"journal\":{\"name\":\"Brain injury\",\"volume\":\" \",\"pages\":\"610-617\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain injury\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02699052.2025.2460740\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain injury","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02699052.2025.2460740","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：观察性研究表明，饮酒会增加创伤性脑损伤（TBI）的风险；然而，这种关联的因果关系尚不清楚。目的：本研究旨在确定哪种饮酒模式是影响TBI的主要因素。方法：采用双样本孟德尔随机化（MR）来评估饮酒模式（酒精消费、滥用和摄入频率）是否与TBI风险有因果关系。结果：MR分析显示酒精摄入频率[比值比（OR） 0.806, 95%可信区间（CI）： 0.665-0.978, p = 0.028， β值：-0.215,se: 0.098]、每周饮酒（OR 1.772, 95% CI: 1.140-2.753, p = 0.011， β值：0.572,se: 0.225）和酒精滥用（OR 1.095, 95% CI: 1.006-1.192, p = 0.035， β值：0.091,se: 0.043）对TBI有因果关系。此外，没有观察到饮酒（OR 0.730, 95% CI: 0.264-2.025, p = 0.546， β值：-0.314,se: 0.520）或平均每月饮酒（OR 1.138, 95% CI: 0.805-1.609, p = 0.463， β值：0.130,se: 0.177）对TBI的因果影响。同样，脑外伤对酒精摄入量的影响在统计学上也不显著。结论：饮酒模式，包括酒精摄入频率和滥用，影响TBI，而TBI很少影响饮酒模式。
Relationship between alcohol use and traumatic brain injury: evidence from Mendelian randomization.
Background: Observational studies suggest that alcohol consumption increases the risk of traumatic brain injury (TBI); however, the causality of this association remains unclear.
Objectives: This study aimed to identify which drinking pattern is the primary factor influencing TBI.
Method: Two-sample Mendelian randomization (MR) was used to assess whether drinking patterns (alcohol consumption, abuse, and intake frequency) are causally associated with TBI risk.
Results: MR analysis revealed causal effects of alcohol intake frequency [odds ratio (OR) 0.806, 95% confidence interval (CI): 0.665-0.978, p = 0.028, beta: -0.215, se: 0.098], alcohol drinks per week (OR 1.772, 95% CI: 1.140-2.753, p = 0.011, beta: 0.572, se: 0.225), and alcohol abuse (OR 1.095, 95% CI: 1.006-1.192, p = 0.035, beta: 0.091, se: 0.043) on TBI. Additionally, no causal effect of alcohol consumption (OR 0.730, 95% CI: 0.264-2.025, p = 0.546, beta: -0.314, se: 0.520) or average monthly alcohol intake (OR 1.138, 95% CI: 0.805-1.609, p = 0.463, beta: 0.130, se: 0.177) on TBI was observed. Similarly, the effects of TBI on alcohol intake were statistically non-significant.
Conclusion: Drinking patterns, including alcohol intake frequency and abuse, influence TBI, whereas TBI rarely influences drinking patterns.
期刊介绍：
Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
