2023年批准的新药的合成方法

IF 6.8 1区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Medicinal Chemistry Pub Date : 2025-02-03 DOI:10.1021/acs.jmedchem.4c02079

Scott P. France, Erick A. Lindsey, Emma L. McInturff, Simon Berritt, Jacob DeForest, Andrew C. Flick, Sarah Fink, Tony S. Gibson, Kaitlyn Gray, Aran K. Hubbell, Amber M. Johnson, Yiyang Liu, Subham Mahapatra, Rebecca B. Watson, Zhiyao Zhou

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引用次数: 0

摘要

本综述是年度系列的下一部分，该系列讨论了2023年全球批准的28种小分子药物的合成途径。对每种药物的作用机制、发现和开发的历史，以及在主要或专利文献中发表的最有可能用于临床研究或开发的合成方法的简要描述都包括在内。合成化学用于将复杂的中间体转化为活性化合物或从基本的基本化学物质中合成新药，对于向患者提供新药和疾病治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthetic Approaches to the New Drugs Approved during 2023

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Synthetic Approaches to the New Drugs Approved during 2023

This review is the next installment of an annual series that discusses the synthetic routes to access 28 small molecule drugs that were approved worldwide in 2023. A brief description of each drug’s mechanism of action, the history of its discovery and development, and the synthetic approaches published in primary or patent literature that were most likely used for clinical studies or development are included. Synthetic chemistry, used to convert complex intermediates to active compounds or build a new drug from basic building block chemicals, is critical to delivery of new drugs and treatments for disease to patients.

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来源期刊

Journal of Medicinal Chemistry 医学-医药化学

CiteScore

4.00

自引率

11.00%

发文量

804

审稿时长

1.9 months

期刊介绍： The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.