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Zn(OTf)2 催化多取代供体-受体环丙烷与蒽的 (4+4) 环缩合非对映选择性合成苯并氮杂环烷烃

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemical Communications Pub Date : 2025-02-03 DOI:10.1039/D4CC06690A
Xuelian Huang, Gaosheng Yang and Zhuo Chai
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引用次数: 0

摘要

Zn(OTf)2催化邻苯二酚与2-（反式-1-芳基-2-芳基环丙基）丙二酸酯进行（4+4）环缩合反应，得到一系列具有氧桥式八元环的多环苯并杂嗪，收率高，具有独特的非对映选择性。这些产物的进一步合成操作可以快速获得各种有用的杂环分子支架。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diastereoselective synthesis of benzazocines by Zn(OTf)2-catalyzed (4+4) cyclocondensation of multisubstituted donor–acceptor cyclopropanes with anthranils†

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Diastereoselective synthesis of benzazocines by Zn(OTf)2-catalyzed (4+4) cyclocondensation of multisubstituted donor–acceptor cyclopropanes with anthranils†

A Zn(OTf)2-catalyzed (4+4) cyclocondensation of anthranils with 2-(trans-1-aroyl-2-arylcyclopropyl)malonates delivers a range of polycyclic benzazocines featuring an oxa-bridged eight-membered ring in excellent yields and with exclusive diastereoselectivity. Further synthetic manipulations of these products enable rapid access to diverse useful heterocyclic molecular scaffolds.

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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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