关节软骨光学特性与组织生物力学参数的关系。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Iman Kafian-Attari, Mohammad Ebrahimi, Ervin Nippolainen, Arash Mirhashemi, Petri Paakkari, Florian Bergmann, Florian Foschum, Alwin Kienle, Juha Töyräs, Isaac Afara
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引用次数: 0

摘要

本研究探讨关节软骨的光学特性与其生物力学参数之间的关系。通过光学测量和蒙特卡罗模拟,估计了关节软骨的吸收系数和减少散射系数,以及光子的平均最大穿透深度、平均最大横向扩散和平均路径长度。通过多步应力松弛测量和纤维增强孔弹性建模,估计了组织的平衡和瞬时模量、初始纤维网络、应变依赖纤维网络和非纤维网络模量以及初始和变形依赖的渗透率。利用预测回归模型评估光学特性与生物力学参数之间的关系。在减少的散射系数、平均最大穿透深度、平均最大横向扩散和光子的平均路径长度与平衡、瞬时和初始纤维网络模量之间存在很强的关系。我们将这种关系归因于胶原纤维是组织散射和生物力学特性的主要贡献者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue

This study investigates the relationship between the optical properties of articular cartilage with its biomechanical parameters. The absorption and reduced scattering coefficients of articular cartilage, and average maximum penetration depth, average maximum lateral spread, and average path length of photons were estimated by optical measurements and Monte Carlo simulation. The equilibrium and instantaneous moduli, and initial fibrillar network, strain-dependent fibrillar network, and nonfibrillar network moduli, and initial and deformation-dependent permeability of the tissue were estimated by multistep stress-relaxation measurement and fibril-reinforced poroelastic modeling. The relationship between the optical properties and biomechanical parameters was assessed using predictive regression modeling. A strong relationship was found between reduced scattering coefficients, averaged maximum penetration depth, averaged maximum lateral spread, and average path length of photons with equilibrium, instantaneous, and initial fibrillar network moduli. We attribute this relationship to the collagen fibers as the main contributor to the scattering and biomechanical properties of the tissue.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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