便携式Nd:YAG激光增强光声光谱传感乳腺组织:肿瘤治疗。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Suhel Khan, Sramana Mukhopadhyay, M. S. Ansari, R. K. Patidar, Saikat Das, Srivathsan Vasudevan
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引用次数: 0

摘要

在光声(PA)系统中,固体激光器因其高能量和相干性而成为产生光的首选。然而,传统的Nd:YAG激光器体积庞大,复杂且昂贵。本文介绍了一种便携式替代方案:带有内部电源的定制Nd:YAG激光器,提供0-30 a电流脉冲,脉冲宽度为1500 μs,提供高效的热管理。口袋电池驱动器产生10 ns脉冲,激光能量密度为3.84 mJ/cm2。应用于无创乳腺癌诊断,正常、纤维化和肿瘤组织的三种不同样本的峰值频率分别为0.23±0.1、0.26±0.13和1.80±0.14 MHz。除了主要的频率峰外,PASR光谱的光谱能量也被研究来表征乳腺组织样品。开发的激光成功区分癌,纤维囊性疾病,和正常乳腺组织基于定量光谱参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics

Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics

A solid-state laser is preferred for generating light in a photoacoustic (PA) system because of its high energy and coherence. However, conventional Nd:YAG lasers are bulky, complex, and expensive. This article introduces a portable alternative: a custom-built Nd:YAG laser with an in-house power supply that delivers 0–30 A current pulses with a 1500 μs pulse width, providing efficient thermal management. A pockels cell driver generates 10 ns pulses with 3.84 mJ/cm 2 laser energy density. Implemented for noninvasive breast cancer diagnosis, The peak frequency obtained from three different samples was 0.23 ± 0.1, 0.26 ± 0.13, and 1.80 ± 0.14 MHz, respectively, for Normal, Fibrotic, and Tumor tissues. In addition to the dominant frequency peaks the spectral energy of the PASR spectra has also been investigated to characterize the breast tissue samples. The developed laser successfully differentiates between carcinoma, fibrocystic disease, and normal breast tissue based on quantitative PA spectral parameters.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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