地狱：转录哨兵。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-04-01 Epub Date: 2025-01-30 DOI:10.1016/j.tcb.2025.01.004

Selene Mallia, Giulia Gambarelli, Alessia Ciarrocchi, Valentina Fragliasso

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引用次数: 0

摘要

染色质重塑酶HELicase Lymphoid Specific （HELLS）的作用历来与DNA甲基化和DNA损伤修复有关。然而，最近的研究揭示了HELLS在转录调控中的一个意想不到的、多模式的直接参与。这篇论坛文章旨在讨论HELLS如何通过不同的和特定环境的机制，调节有利于转录可塑性和表型适应的功能相关基因的表达，最终维护基因组的组织和稳定性。

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HELLS: the transcriptional sentinel.

The role of the chromatin remodeler HELicase Lymphoid Specific (HELLS) has been historically associated with DNA methylation and DNA damage repair. However, recent studies have shed light on an unexpected, multimodal, and direct participation of HELLS in transcriptional regulation. This forum article aims to discuss how, through different and context-specific mechanisms, HELLS modulates the expression of functionally related genes favoring transcriptional plasticity and phenotypic adaptation, ultimately safeguarding the genome organization and stability.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.