淀粉样蛋白- β动态和阿尔茨海默病脑尺度治疗的网络聚集模型。

IF 2.3 4区数学 Q2 BIOLOGY

Journal of Mathematical Biology Pub Date : 2025-02-01 DOI:10.1007/s00285-024-02179-5

Georgia S Brennan, Alain Goriely

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引用次数: 0

摘要

神经退行性疾病与特定蛋白质组装成低聚物和纤维聚集体有关。在大脑层面上，这些蛋白质组合可以在大脑中扩散，并在其他区域播下种子，创造一种自催化的蛋白质进展。这些组装体的生长和运输依赖于可靶向治疗的各种机制。在这里，我们使用空间扩展的核-聚集-碎片模型来研究朊病毒样神经退行性蛋白在大脑中的扩散动力学，以研究不同药物对全脑阿尔茨海默病进展的影响。

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A network aggregation model for amyloid- β dynamics and treatment of Alzheimer's diseases at the brain scale.

Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer's disease progression.

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来源期刊

Journal of Mathematical Biology 生物-生物学

CiteScore

3.30

自引率

5.30%

发文量

120

审稿时长

6 months

期刊介绍： The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena. Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.