空间多组学对骨髓微环境的解读。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2025-01-30 DOI:10.1016/j.semcdb.2025.01.001

Raymond K.H. Yip , Edwin D. Hawkins , Rory Bowden , Kelly L. Rogers

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引用次数: 0

摘要

组织微环境是指细胞、结构成分和信号分子的复杂组合共同作用以支持特定生物活性的局部组织区域。一个典型的例子是骨髓微环境，特别是造血干细胞（HSC）生态位，由于其在支持终身血细胞生成和恶性细胞生长方面的关键作用，因此引起了极大的兴趣。在这篇综述中，我们总结了目前对HSC生态位生物学的理解，重点介绍了从先进的成像和基因组技术中获得的见解。我们还讨论了新兴技术的潜力，如空间多组学，以前所未有的细节揭示骨髓结构。

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Towards deciphering the bone marrow microenvironment with spatial multi-omics

The tissue microenvironment refers to a localised tissue area where a complex combination of cells, structural components, and signalling molecules work together to support specific biological activities. A prime example is the bone marrow microenvironment, particularly the hematopoietic stem cell (HSC) niche, which is of immense interest due to its critical role in supporting lifelong blood cell production and the growth of malignant cells. In this review, we summarise the current understanding of HSC niche biology, highlighting insights gained from advanced imaging and genomic techniques. We also discuss the potential of emerging technologies such as spatial multi-omics to unravel bone marrow architecture in unprecedented detail.

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.