塑造免疫:母体肠道细菌对胎儿免疫发育的影响。

IF 7.9 2区 医学 Q1 IMMUNOLOGY
Marijke M Faas, Alexandra M Smink
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引用次数: 0

摘要

胎儿免疫反应的发展是一个高度复杂的过程。在这篇综述中,我们描述了胎儿免疫反应的发展以及母体肠道细菌在这一过程中的作用。与先前认为胎儿免疫反应是惰性的观点相反,现在认为胎儿免疫反应对母体和异体抗原具有独特的耐受性,但能够对感染性病原体(如细菌)产生反应。这是通过T细胞向调节性T细胞而不是向效应T细胞发育来完成的,但也通过功能性先天免疫细胞(如单核细胞和NK细胞)的存在来完成。此外,在胎儿中,CD8 + T细胞和记忆T细胞对先天免疫细胞的编程与对适应性免疫细胞的编程不同。母体肠道细菌通过产生细菌产物和代谢物,通过胎盘进入胎儿并影响胎儿免疫反应的发育,在形成胎儿免疫反应中发挥重要作用。对这些产品如何以及何时影响胎儿免疫反应的深入了解,可能会开启新的治疗选择,即使用益生菌或益生菌来影响母体肠道细菌,从而影响胎儿免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.

The development of the fetal immune response is a highly complex process. In the present review, we describe the development of the fetal immune response and the role of the maternal gut bacteria in this process. In contrast to the previous belief that the fetal immune response is inert, it is now thought that the fetal immune response is uniquely tolerant to maternal and allo-antigens, but able to respond to infectious agents, such as bacteria. This is accomplished by the development of T cells toward regulatory T cells rather than toward effector T cells, but also by the presence of functional innate immune cells, such as monocytes and NK cells. Moreover, in fetuses there is different programming of CD8 + T cells and memory T cells toward innate immune cells rather than to adaptive immune cells. The maternal gut bacteria are important in shaping the fetal immune response by producing bacterial products and metabolites that pass the placenta into the fetus and influence development of the fetal immune response. Insight into how and when these products affect the fetal immune response may open new treatment options with pre- or probiotics to affect the maternal gut bacteria and therewith the fetal immune response.

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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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