牙周病与妊娠糖尿病有关吗?探索证据。

Q3 Dentistry
Lata Goyal, Mehak Gupta, Shipra Gupta
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引用次数: 0

摘要

数据来源:截至2024年4月,通过PubMed、Cochrane、Embase和Virtual health图书馆进行了全面的文献检索。文章全文选择了英语、西班牙语、法语和葡萄牙语。仅纳入观察性研究。研究选择:所有选择的研究都是观察性的,并以英语、西班牙语、法语或葡萄牙语全文发表。根据美国糖尿病协会的指南诊断妊娠期糖尿病,由专家人员根据国际标准诊断牙周病。数据提取和合成:由两名审查员进行数据提取和合成。为了确定牙周病和妊娠期糖尿病之间的关系,采用95%可信区间的优势比。采用方差逆固定效应模型。如果使用Q统计量的同质性检验和I2显示异质性(p),则使用Der Simonian和Laird随机效应模型。结果:文献检索共发现187篇研究,随后删除重复,留下176篇研究。根据纳入和排除标准对文章进行筛选后,最终有11篇文章被纳入系统评价。在纳入的11项研究中,3项为队列研究,8项为病例对照研究。共评估了2032例患者,其中572例发生妊娠期糖尿病。10项研究被认为是高质量的,1项研究被认为是中等质量的。11项研究中有6项报告了牙周病和妊娠期糖尿病之间的联系,而5项没有产生任何有意义的发现。结果显示p值小于0.0017,优势比(OR)为1.83,95%可信区间(CI)为1.25 ~ 2.69。结论:本系统综述和荟萃分析提示牙周病与妊娠期糖尿病相关。几项研究支持牙周病的存在增加妊娠期糖尿病发生风险的假设,在不确定地建立同样的假设之前需要更多强有力的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is periodontal disease associated with gestational diabetes? Exploring the evidence
A comprehensive literature search was carried out via PubMed, Cochrane, Embase and Virtual health libraries till April 2024. Articles with full text were selected in English, Spanish, French, and Portuguese language. Only observational studies were included. All selected studies were observational in nature and published in full text in English, Spanish, French, or Portuguese language. Gestational diabetes mellitus was diagnosed based on the American Diabetes Association’s guidelines, and periodontal disease was diagnosed using international criteria by expert personnel. Two examiners did data extraction and synthesis. To identify the relationship between periodontal disease and gestational diabetes mellitus, an Odds ratio with 95% confidence interval was used. The inverse of the variance fixed effects model was applied. The Der Simonian and Laird random effects model was used if the homogeneity test using the Q statistic and the I2 revealed heterogeneity (p < 0.1). Eggers’s test was used for bias assessment, and a funnel plot was also used to determine publication bias. Newcastle -Ottawa criteria were used to evaluate the quality of the included studies. Stata 17 was used in the entire data extraction process. Later on, a meta-analysis was done with seven articles with an adjusted Odds ratio. A total of 187 studies were found after a literature search, later on, duplicates were removed, leaving behind 176 studies. After screening the articles based on inclusion and exclusion criteria, 11 articles were finally included in the systematic review. Out of 11 included studies, 3 studies were cohort studies, and 8 were case-control. A total of 2032 patients were evaluated, out of which 572 developed gestational diabetes mellitus. 10 studies were considered to be of high quality, and one study was of intermediate quality. Six of the eleven studies reported a link between periodontal disease and gestational diabetes mellitus, whereas five did not yield any meaningful findings. The results showed a statistically significant p-value of less than 0.0017 and an odds ratio (OR) of 1.83 with a 95% confidence interval (CI) of 1.25 to 2.69. This systematic review and meta-analysis suggest that periodontal disease is related to gestational diabetes mellitus. Several studies support the hypothesis that the presence of periodontal disease increases the risk of the development of gestational diabetes mellitus, more strong evidence is required before the same is established inconclusively.
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来源期刊
Evidence-based dentistry
Evidence-based dentistry Dentistry-Dentistry (all)
CiteScore
2.50
自引率
0.00%
发文量
77
期刊介绍: Evidence-Based Dentistry delivers the best available evidence on the latest developments in oral health. We evaluate the evidence and provide guidance concerning the value of the author''s conclusions. We keep dentistry up to date with new approaches, exploring a wide range of the latest developments through an accessible expert commentary. Original papers and relevant publications are condensed into digestible summaries, drawing attention to the current methods and findings. We are a central resource for the most cutting edge and relevant issues concerning the evidence-based approach in dentistry today. Evidence-Based Dentistry is published by Springer Nature on behalf of the British Dental Association.
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