肿瘤浸润性B淋巴细胞在肿瘤免疫治疗中的动态作用。

IF 4.6 2区医学 Q2 IMMUNOLOGY

Cancer Immunology, Immunotherapy Pub Date : 2025-02-01 DOI:10.1007/s00262-024-03936-7

Shishengnan Song, Chong Wang, Yangchao Chen, Xiaorong Zhou, Yi Han, Haijian Zhang

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引用次数: 0

摘要

肿瘤微环境中B细胞惊人的多样性是基于B细胞的免疫疗法多样化发展的基础。在这里，我们重点阐明四种肿瘤浸润性B淋巴细胞介导的肿瘤干预机制。幼稚B细胞呈递初始抗原，生发中心B细胞亚群增强抗体亲和力，免疫球蛋白亚型发挥多种免疫作用，调节性B细胞建立免疫耐受。它们共同反映了癌症免疫变化动态的复杂性。此外，我们还研究了肿瘤浸润B淋巴细胞在免疫治疗中的动态作用及其与预后的关系，为患者的潜在治疗策略提供了新的见解。

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Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy.

The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. Together they reflect the complexity of the changing dynamics of cancer immunity. Additionally, we have investigated the dynamic effects of tumor-infiltrating B lymphocytes in immunotherapy and their relationship to prognosis, providing new insights into potential treatment strategies for patients.

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来源期刊

Cancer Immunology, Immunotherapy 医学-免疫学

CiteScore

10.50

自引率

1.70%

发文量

207

审稿时长

1 months

期刊介绍： Cancer Immunology, Immunotherapy has the basic aim of keeping readers informed of the latest research results in the fields of oncology and immunology. As knowledge expands, the scope of the journal has broadened to include more of the progress being made in the areas of biology concerned with biological response modifiers. This helps keep readers up to date on the latest advances in our understanding of tumor-host interactions. The journal publishes short editorials including "position papers," general reviews, original articles, and short communications, providing a forum for the most current experimental and clinical advances in tumor immunology.