使宠物狗在癌症试验中的双重益处最大化

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-01-31 DOI:10.1038/s41568-025-00792-0

Jennifer A. Lenz, Matthew J. Atherton

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引用次数: 0

摘要

患有癌症的宠物狗已经催化了临床前发现向首次人体试验的转化，突出了比较肿瘤学在同时研究兽医和人类癌症患者方面的独特力量。然而，这种方法的全部潜力尚未得到充分利用。在这里，我们强调了由于在狗身上的试验在肿瘤学方面取得的成就，并讨论了进一步推进比较肿瘤学的步骤。患有癌症的宠物狗有助于比较肿瘤学，加强转化研究。在这篇评论中，Lenz和Atherton强调了比较肿瘤学的成功，强调需要更广泛地应用犬类研究的结果来改善人类癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Maximizing the dual benefit of pet dogs in cancer trials

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Maximizing the dual benefit of pet dogs in cancer trials

Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the unique power of comparative oncology to study veterinary and human patients with cancer in parallel. However, the full potential of this approach has yet to be harnessed. Here we highlight accomplishments in oncology due to trials in dogs and discuss the next steps to advance comparative oncology. Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.