带有三个电子抽离基团的 C-H 亲核物的电化学umpolung 触发烯丙基醇的 1,2-烷基芳基自由基反应

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-01-31 DOI:10.1002/adsc.202401522

Qibin Li, Die Hu, Kun Xu, Cheng-Chu Zeng

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Electrochemical umpolung of C‐H nucleophiles bearing three electron‐withdrawing groups to trigger radical 1,2‐alkylarylations of allylic alcohols

The electrochemical catalyst‐free generation of carbon radicals bearing three electron‐withdrawing groups from the corresponding C‐H nucleophiles remains unexplored. To this end, we report a direct electro‐oxidation strategy to access these electrophilic carbon radicals under catalyst‐free conditions. Enabled by this strategy, the radical 1,2‐alkylarylations of allylic alcohols was realized, affording β‐quaternary ketones with high functional group compatibility. This protocol is operationally simple and also easy to scale up.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.