一项跨诊断研究:快感缺乏症与抑郁症纹状体奖励预期降低有关,但与精神分裂症或双相情感障碍无关。

IF 2.5 3区 医学 Q2 BEHAVIORAL SCIENCES
Anna Daniels, Sarah A Wellan, Anne Beck, Susanne Erk, Carolin Wackerhagen, Nina Romanczuk-Seiferth, Kristina Schwarz, Janina I Schweiger, Andreas Meyer-Lindenberg, Andreas Heinz, Henrik Walter
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引用次数: 0

摘要

快感缺乏症,即快乐的丧失或对奖励缺乏反应,是主要精神疾病的核心症状。纹状体中奖赏处理的改变已经在情绪和精神疾病中被观察到,但快感缺乏是否在诊断上导致了这些缺陷尚不清楚。我们在精神分裂症(SZ)、双相情感障碍(BD)、重度抑郁症(MD)和健康对照(HC)患者中调查了自我报告的快感缺乏与奖赏预期和消费期间神经激活之间的关系。使用货币激励延迟范式,我们获得了227名参与者(18-65岁)的功能磁共振成像数据集,包括SZ (n = 44)、BD (n = 47)、MD (n = 56)和HC (n = 80)患者。为了捕获快感缺乏症,我们将症状检查表-90- r中的三个项目输入探索性因素分析,得到一个快感缺乏症因素。在纹状体兴趣区和探索性全脑(pFWE)内评估快感缺乏和神经激活之间的关联
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.

Anhedonia, i.e., the loss of pleasure or lack of reactivity to reward, is a core symptom of major psychiatric conditions. Altered reward processing in the striatum has been observed across mood and psychotic disorders, but whether anhedonia transdiagnostically contributes to these deficits remains unclear. We investigated associations between self-reported anhedonia and neural activation during reward anticipation and consumption across patients with schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MD), and healthy controls (HC). Using the Monetary Incentive Delay paradigm, we acquired functional magnetic resonance imaging data sets in 227 participants (18-65 years), including patients with SZ (n = 44), BD (n = 47), MD (n = 56), and HC (n = 80). To capture anhedonia, three items of the Symptom Checklist-90-R were entered into exploratory factor analysis, which resulted in a single anhedonia factor. Associations between anhedonia and neural activation were assessed within a striatal region-of-interest and exploratorily across the whole brain (pFWE < .05). Self-reported anhedonia was high in MD, low in HC, and intermediate in SZ and BD. During reward anticipation, anhedonia correlated with reduced striatal activation; however, the correlation depended on diagnostic group. Specifically, the effect was driven by a negative relationship between anhedonia and dorsal striatal (putamen) activity within the MD group; for reward consumption, no correlations were found. Our results indicate that anticipatory anhedonia in MD may relate to reduced behavioral motivation via disrupted encoding of motor plans in the dorsal striatum. Future transdiagnostic research should stratify participants by anhedonia levels to achieve more homogeneous samples in terms of underlying neurobiology.

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来源期刊
CiteScore
5.00
自引率
3.40%
发文量
64
审稿时长
6-12 weeks
期刊介绍: Cognitive, Affective, & Behavioral Neuroscience (CABN) offers theoretical, review, and primary research articles on behavior and brain processes in humans. Coverage includes normal function as well as patients with injuries or processes that influence brain function: neurological disorders, including both healthy and disordered aging; and psychiatric disorders such as schizophrenia and depression. CABN is the leading vehicle for strongly psychologically motivated studies of brain–behavior relationships, through the presentation of papers that integrate psychological theory and the conduct and interpretation of the neuroscientific data. The range of topics includes perception, attention, memory, language, problem solving, reasoning, and decision-making; emotional processes, motivation, reward prediction, and affective states; and individual differences in relevant domains, including personality. Cognitive, Affective, & Behavioral Neuroscience is a publication of the Psychonomic Society.
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