真核生物转录因子中DNA相互作用的机制。

IF 10.4 1区 生物学 Q1 BIOPHYSICS
Victor Muñoz, Rama Reddy Goluguri, Catherine Ghosh, Benjamin Tanielian, Mourad Sadqi
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引用次数: 0

摘要

与原核生物一样,真核生物转录因子必须识别特定的DNA位点,有效地寻找它们,并与它们结合以帮助招募或阻断转录机制。然而,对于真核生物因子,遗传信号极其复杂,分散在庞大的多染色体基因组中,而DNA相互作用发生在染色质重塑事件和表观遗传修饰所定义的不同景观中。真核生物因子具有丰富的内在无序区域,并且在识别短DNA基序和利用开放的DNA相互作用界面作为获取核小体上DNA的途径方面也具有独特性。最近的发现揭示了这些特征对DNA相互作用机制的深刻的、不可预见的影响。在这篇综述中,我们讨论了这些影响以及它们如何将真核生物转录控制范式塑造为混杂信号识别,高度动态相互作用,异质DNA扫描和多位点构象控制之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms for DNA Interplay in Eukaryotic Transcription Factors.

Like their prokaryotic counterparts, eukaryotic transcription factors must recognize specific DNA sites, search for them efficiently, and bind to them to help recruit or block the transcription machinery. For eukaryotic factors, however, the genetic signals are extremely complex and scattered over vast, multichromosome genomes, while the DNA interplay occurs in a varying landscape defined by chromatin remodeling events and epigenetic modifications. Eukaryotic factors are rich in intrinsically disordered regions and are also distinct in their recognition of short DNA motifs and utilization of open DNA interaction interfaces as ways to gain access to DNA on nucleosomes. Recent findings are revealing the profound, unforeseen implications of such characteristics for the mechanisms of DNA interplay. In this review we discuss these implications and how they are shaping the eukaryotic transcription control paradigm into one of promiscuous signal recognition, highly dynamic interactions, heterogeneous DNA scanning, and multiprong conformational control.

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来源期刊
Annual Review of Biophysics
Annual Review of Biophysics 生物-生物物理
CiteScore
21.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.
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