[Predictors of premature aging and the effectiveness of combined physiotherapy].

Premature aging of a person is caused by many reasons, among which great importance is given to chronic somatic diseases. Their presence is largely accompanied by numerous pathological reactions, which are quite difficult to correct by the use of drugs, which, as a rule, have specific therapeutic effects. At the same time, combined physiotherapy is devoid of these disadvantages and can activate sanogenetic processes.

Objective: To analyze predictors of pathological manifestations of premature aging and to evaluate predictors of the effectiveness of combined physiotherapy to reduce the rate of premature aging.

Material and methods: The studies were conducted at the Scientific and Clinical Center 1 of the B.V. Petrovsky Russian Scientific Center of Surgery with the participation of 80 patients (46 men and 34 women) aged 20 to 90 years. After signing voluntary informed consent for a special study with the processing of their personal data, all patients underwent a comprehensive clinical, laboratory and functional examination. Using the method of simple fixed randomization, patients were divided into two groups. The comparison group (n=40) received moderate physical activity, reduced calorie intake and vitamin therapy. Patients of the main group (n=40) additionally received a physiotherapeutic complex, which included multimodal effects using the Alpha LED Oxy Light-Spa device, hyper-hypoxytherapy, pressotherapy, dry carbon dioxide baths. Preventive courses were repeated twice with an interval of 6 months. All studies were conducted before and 6 months after the completion of each preventive course. Multiple linear and logistic regression analysis was used to identify predictors.

Results: Premature aging processes are associated with the presence of chronic somatic pathology, which disrupts insulin regulation of carbohydrate and lipid metabolism, increases the rate of aging and is accompanied by activation of inflammation processes and a decrease in the relative length of telomeres. Correlation and regression analysis made it possible to isolate the main predictors of premature aging, the regression of which became one of the goals of physiotherapeutic effects on these parameters. It has been proven that the effectiveness of combined physiotherapy increases with more significant disorders caused by the presence of chronic somatic pathology.

Conclusion: The leading role of insulin resistance in the formation of pathological reactions characterizing premature aging in patients with chronic somatic diseases has been revealed. Analysis of dynamic processes in the use of combined physiotherapy and predictors of its effectiveness allowed us to assume that physiotherapeutic effects have a therapeutic effect to a greater extent than a preventive one.