从红树林沉积物衍生真菌Lecanicillium kalimantanense SCSIO 41702中发现的两个新的氨基酸衍生肟。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2026-01-17 Epub Date: 2025-01-25 DOI:10.1080/14786419.2025.2459816

Xu-Meng Ren , Lin-Fang Zhong , Ke-Yue Wu , Xiao Liang , Shu-Hua Qi

引用次数: 0

摘要

从红树林沉积物来源的真菌Lecanicillium kalimantense SCSIO 41702中分离出两个新的氨基酸衍生的氧亚胺N-(2-hydroxyimino-4-methyl-pentanoyl)- l-异亮氨酸(1)和N-(2-hydroxyimino-3-phenylpropanoyl)- l-苯丙氨酸(2)，以及两个已知的类似物(E)-N-(2-hydroxyimino-3-phenylpropanoyl)- l-苯丙氨酸(4)。通过光谱分析确定了它们的结构。用Marfey方法确定了1和2的绝对构型。化合物1和2对lps诱导的NO产生具有中等抑制活性。

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Two new amino acid-derived oximes from the mangrove-sediment-derived fungus Lecanicillium kalimantanense SCSIO 41702

Two new amino acid-derived oximes N-(2-hydroxyimino-4-methylpentanoyl)-L-isoleucine (1) and N-(2-hydroxyimino-4-methylpentanoyl)-L-leucine (2), along with two known analogues (E)-N-(2-hydroxyimino-3-phenylpropanoyl)-L-phenylalanine (3) and methyl (E)-N- (2-hydroxyimino-3-phenylpropanoyl)-L-phenylalaninate (4), were isolated from the mangrove-sediment-derived fungus Lecanicillium kalimantanense SCSIO 41702. Their structures were determined by spectroscopic analysis. The absolute configurations of 1 and 2 were determined by Marfey’s method. Compounds 1 and 2 showed medium inhibitory activity against LPS-induced NO production.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.