评估初榨椰子油对慢性牙周炎患者病毒载量、细菌载量和炎症介质水平的影响-一项临床研究。

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI:10.1016/j.jobcr.2025.01.004

Monika M , Rudhra K , Vennila K , Elanchezhiyan , Sri Harini P , S. Shakeron

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引用次数: 0

摘要

背景和目的：牙周炎和龋齿是最常见的口腔疾病，慢性牙周炎是一种多因素的感染性疾病，可导致牙齿支撑结构炎症、附着物逐渐丧失和骨吸收。慢性牙周炎是由一组致病微生物引起的。本研究旨在评估初拌椰子油（VCO）与氯己定（CHX）漱口水和蒸馏水相比，在减少慢性牙周炎的微生物负荷和炎症介质方面的功效。方法：30例慢性牙周炎患者随机分为3组。A组为对照组，使用蒸馏水进行口腔冲洗，B组使用洗必泰漱口水，C组使用初榨椰子油进行油拔。术前收集所有参与者的龈下菌斑样本，然后进行完整的洗牙和牙根刨平。术后4周采集标本。处理前和处理后的样品均进行实时PCR （rtPCR）和酶联免疫吸附测定（ELISA），以量化病毒和细菌载量以及关键炎症介质的水平。结果：与蒸馏水组相比，VCO和CHX组的病毒载量、细菌载量和炎症介质均显著减少。VCO组和CHX组的降低具有统计学意义，两种干预措施的疗效相当。结论：初磨椰子油可显著降低慢性牙周炎患者的微生物和炎症标志物，其疗效与氯己定漱口水相似。鉴于其相当的治疗效果和减少的副作用，VCO提出了一个可行的替代氯己定治疗慢性牙周炎。

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Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study

Background and objective

Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chronic periodontitis is driven by a consortium of pathogenic microorganisms. This study aimed to evaluate the efficacy of virgin coconut oil (VCO) pulling in reducing the microbial load and inflammatory mediators responsible for chronic periodontitis, in comparison to chlorhexidine (CHX) mouthwash and distilled water.

Methods

Thirty patients diagnosed with chronic periodontitis were randomly allocated into three groups. Group A served as the control and used distilled water for oral rinsing, Group B used chlorhexidine mouthwash, and Group C performed oil pulling with virgin coconut oil. Pre-operative subgingival plaque samples were collected from all participants, followed by complete scaling and root planing. Post-operative samples were collected after four weeks. Both pre- and post-treatment samples were subjected to real-time PCR (rtPCR) and enzyme-linked immunosorbent assay (ELISA) to quantify viral and bacterial loads, as well as levels of key inflammatory mediators.

Results

A significant reduction in viral load, bacterial load, and inflammatory mediators was observed in both the VCO and CHX groups compared to the distilled water group. The reductions in the VCO and CHX groups were statistically significant, with comparable efficacy between the two interventions.

Conclusion

Virgin coconut oil pulling demonstrated a significant reduction in microbial and inflammatory markers in patients with chronic periodontitis, showing similar efficacy to chlorhexidine mouthwash. Given its comparable therapeutic effects and reduced side effect profile, VCO presents a viable alternative to chlorhexidine for managing chronic periodontitis.

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.