改善成人帕金森病患者运动症状的最佳运动剂量和类型：网络荟萃分析

IF 3 2区医学 Q1 SPORT SCIENCES

Journal of science and medicine in sport Pub Date : 2025-04-01 DOI:10.1016/j.jsams.2025.01.003

Junyu Wang , Yuan Yuan , Ting Xie , Ligong Zhang , Hong Xu , Shu-Cheng Lin , Yong Yang , Dong Zhu , Jie Zhuang

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引用次数: 0

摘要

目的：本研究旨在评估不同运动类型与帕金森病患者运动症状缓解之间的量效关系。设计：采用随机对照试验，进行系统评价和网络荟萃分析，比较12种运动类型对帕金森病患者运动症状的影响。方法：系统检索PubMed、Medline、Embase、PsycINFO、Cochrane Library和Web of Science，检索截止日期为2024年9月10日。共纳入81项试验，涉及4596名患者。计算95 %可信区间的平均差异，并使用网络元分析的置信度评估证据质量。采用最小临床重要差异评价临床疗效。结果：整体运动症状改善的最佳运动剂量为1300 MET-min/周（平均差值：-6.07,95 %可信区间：-8.10至-4.01）。850 MET-min/周的舞蹈提供了最大的改善（平均差异：-11.18,95 %可信区间：-16.01至-6.22）。对于体重支持训练、舞蹈、阻力训练和感觉运动，剂量低至60-100 MET-min/周，效果显著。最小临床重要差异是在整体运动剂量超过670 MET-min/周时实现的，而在特定类型的低剂量：有氧运动（1100 MET-min/周），体重支持（420 MET-min/周）和舞蹈（230 MET-min/周）。结论：缓解帕金森病患者运动症状的最佳运动剂量为1300 MET-min/周，舞蹈在850 MET-min/周时最有效。这些发现为帕金森病的治疗提供了循证建议。

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Optimal dose and type of exercise to improve motor symptoms in adults with Parkinson's disease: A network meta-analysis

Objectives

This study aimed to evaluate the dose-response relationship between different exercise types and the alleviation of motor symptoms in Parkinson’s Disease patients.

Design

A systematic review and network meta-analysis were conducted to compare the effects of 12 exercise types on motor symptoms in Parkinson’s Disease patients using randomized controlled trials.

Methods

A systematic search was conducted across PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science until September 10, 2024. A total of 81 trials involving 4596 patients were included. Mean differences with 95 % credible intervals were calculated, and evidence quality was assessed using Confidence in Network Meta-Analysis. The Minimum Clinically Important Difference was used to assess clinical efficacy.

Results

The optimal exercise dose for overall motor symptom improvement was 1300 MET-min/week (mean difference: − 6.07, 95 % credible intervals: − 8.10 to − 4.01). Dance at 850 MET-min/week provided the greatest improvement (mean difference: − 11.18, 95 % credible intervals: − 16.01 to − 6.22). Significant improvements were seen with doses as low as 60–100 MET-min/week for body weight support training, dance, resistance training, and sensory exercise. The Minimum Clinically Important Difference was achieved with doses exceeding 670 MET-min/week for overall exercise, and at lower doses for specific types: aerobic exercise (1100 MET-min/week), body weight support (420 MET-min/week), and dance (230 MET-min/week).

Conclusions

The optimal exercise dose for alleviating motor symptoms in Parkinson’s Disease patients is 1300 MET-min/week, with dance being most effective at 850 MET-min/week. These findings provide evidence-based recommendations for Parkinson’s Disease management.

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来源期刊

Journal of science and medicine in sport 医学-运动科学

CiteScore

7.40

自引率

10.00%

发文量

198

审稿时长

48 days

期刊介绍： The Journal of Science and Medicine in Sport is the official journal of Sports Medicine Australia (SMA) and is an an international refereed research publication covering all aspects of sport science and medicine. The Journal considers for publication Original research and Review papers in the sub-disciplines relating generally to the broad sports medicine and sports science fields: sports medicine, sports injury (including injury epidemiology and injury prevention), physiotherapy, podiatry, physical activity and health, sports science, biomechanics, exercise physiology, motor control and learning, sport and exercise psychology, sports nutrition, public health (as relevant to sport and exercise), and rehabilitation and injury management. Manuscripts with an interdisciplinary perspective with specific applications to sport and exercise and its interaction with health will also be considered.