反运动超快速定量MRI在神经系统疾病成像中的应用:来自亨廷顿病的见解。

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Fei Wu, Haiyang Luo, Xiao Wang, Qinqin Yang, Yuchuan Zhuang, Liangjie Lin, Yanbo Dong, Andrey Tulupov, Yong Zhang, Shuhui Cai, Zhong Chen, Congbo Cai, Jianfeng Bao, Jingliang Cheng
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引用次数: 0

摘要

背景:传统的定量MRI (qMRI)扫描耗时且对运动高度敏感,这给亨廷顿病(HD)等非随意运动个体的定量成像带来了巨大挑战。目的:评估我们开发的超快速qMRI技术,多重重叠回声脱离(MOLED)在克服不自主头部运动方面的潜力及其定量评估HD组织变化的能力。研究类型:前瞻性。幻影/受试者:幻影包括13管不同浓度的MnCl2, 5名健康志愿者(男/女:1/4),22名HD患者(男/女:14/8)和27名健康对照(男/女:15/12)。场强/序列:3.0 T。MOLED-T2序列、MOLED-T2*序列、t2加权自旋回波序列、t1加权梯度回波序列、t2 -暗流体序列。评估:将t1加权图像重建为高分辨率图像,然后进行分割以划定感兴趣区域(roi)。随后,将MOLED T2和T2*映射与高分辨率图像对齐,利用变换矩阵和翘曲场将roi转换到MOLED图像空间中。最后从MOLED弛豫图中提取T2和T2*值。统计学检验:Bland-Altman分析、独立t检验、Mann-Whitney U检验、Pearson相关分析、Spearman相关分析,P结果:MOLED-T2和MOLED-T2*序列具有良好的准确性(Meandiff = - 0.20%, SDdiff = 1.05%, Meandiff = -1.73%, SDdiff = 10.98%)和良好的重复性(平均类内相关系数分别为0.856和0.853)。更重要的是,在所有HD患者中,即使出现明显的头部运动,MOLED T2和T2*图仍然没有伪影。此外,HD和对照组在多个roi中的T2和T2*值也存在显著差异。数据结论:MOLED的超快速扫描能力有效减轻了头部运动的影响,为高清定量成像提供了强大的解决方案。此外,MOLED得到的T2和T2*值为定量组织变化提供了强大的能力。简单的语言总结:定量MRI扫描耗时且对运动敏感。因此,获得定量图像是具有不自主运动的患者,如那些患有亨廷顿病(HD)的挑战。为此,一种新开发的MOLED技术被引入,有望通过超快速扫描抵抗运动。该技术证明了出色的准确性和可重复性,重要的是所有HD患者的MOLED图都保持无伪影。此外,HD和对照组之间的T2和T2 *值在roi之间存在显著差异。MOLED对运动的强大抵抗力使其特别适合于易发生不自主运动的患者的定量评估。证据水平:2技术功效:1期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of Anti-Motion Ultra-Fast Quantitative MRI in Neurological Disorder Imaging: Insights From Huntington's Disease.

Background: Conventional quantitative MRI (qMRI) scan is time-consuming and highly sensitive to movements, posing great challenges for quantitative images of individuals with involuntary movements, such as Huntington's disease (HD).

Purpose: To evaluate the potential of our developed ultra-fast qMRI technique, multiple overlapping-echo detachment (MOLED), in overcoming involuntary head motion and its capacity to quantitatively assess tissue changes in HD.

Study type: Prospective.

Phantom/subjects: A phantom comprising 13 tubes of MnCl2 at varying concentrations, 5 healthy volunteers (male/female: 1/4), 22 HD patients (male/female: 14/8) and 27 healthy controls (male/female: 15/12).

Field strength/sequence: 3.0 T. MOLED-T2 sequence, MOLED-T2* sequence, T2-weighted spin-echo sequence, T1-weighted gradient echo sequence, and T2-dark-fluid sequence.

Assessment: T1-weighted images were reconstructed into high-resolution images, followed by segmentation to delineate regions of interest (ROIs). Subsequently, the MOLED T2 and T2* maps were aligned with the high-resolution images, and the ROIs were transformed into the MOLED image space using the transformation matrix and warp field. Finally, T2 and T2* values were extracted from the MOLED relaxation maps.

Statistical tests: Bland-Altman analysis, independent t test, Mann-Whitney U test, Pearson correlation analysis, and Spearman correlation analysis, P < 0.05 was considered statistically significant.

Results: MOLED-T2 and MOLED-T2* sequences demonstrated good accuracy (Meandiff = - 0.20%, SDdiff = 1.05%, and Meandiff = -1.73%, SDdiff = 10.98%, respectively), and good repeatability (average intraclass correlation coefficient: 0.856 and 0.853, respectively). More important, MOLED T2 and T2* maps remained artifact-free across all HD patients, even in the presence of apparent head motions. Moreover, there were significant differences in T2 and T2* values across multiple ROIs between HD and controls.

Data conclusion: The ultra-fast scanning capabilities of MOLED effectively mitigate the impact of head movements, offering a robust solution for quantitative imaging in HD. Moreover, T2 and T2* values derived from MOLED provide powerful capabilities for quantifying tissue changes.

Plain language summary: Quantitative MRI scan is time-consuming and sensitive to movements. Consequently, obtaining quantitative images is challenging for patients with involuntary movements, such as those with Huntington's Disease (HD). In response, a newly developed MOLED technique has been introduced, promising to resist motion through ultra-fast scan. This technique has demonstrated excellent accuracy and reproducibility and importantly all HD patient's MOLED maps remained artifacts-free. Additionally, there were significant differences in T2 and T2∗ values across ROIs between HD and controls. The robust resistance of MOLED to motion makes it particularly suitable for quantitative assessments in patients prone to involuntary movements.

Level of evidence: 2 TECHNICAL EFFICACY: Stage 1.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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