{"title":"色氨酸感知受体GPR142的表达水平直接受促炎细胞因子在生长素产生细胞中的调节。","authors":"Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando-Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka-Aki Matsuoka, Hiroki Yamaue, Takashi Akamizu","doi":"10.1002/2211-5463.13973","DOIUrl":null,"url":null,"abstract":"<p><p>GPR142 is a tryptophan-sensing receptor that has been implicated in the regulation of inflammation. In this study, we investigated the relationships between inflammatory cytokine and GPR142 expression by using cellular, animal models, and human stomach samples. We found that addition of TNF-α, IL-6, and IL-1β into the culture of ghrelin-producing cell line, MGN3-1 cells, increased GPR142 mRNA expression levels. Lipopolysaccharide (LPS) injection to mice significantly increased GPR142 expression in the stomach, confirming the results observed in the cellular model. GPR142 mRNA expression levels in the stomach samples of morbidly obese patients were positively correlated with TNF-α, IL-6, and IL-1β mRNA levels. Taken together our results suggest that GPR142 expression is under the direct control of proinflammatory cytokines and support further investigation of GPR142 potential roles in inflammation.</p>","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tryptophan-sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin-producing cells.\",\"authors\":\"Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando-Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka-Aki Matsuoka, Hiroki Yamaue, Takashi Akamizu\",\"doi\":\"10.1002/2211-5463.13973\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>GPR142 is a tryptophan-sensing receptor that has been implicated in the regulation of inflammation. In this study, we investigated the relationships between inflammatory cytokine and GPR142 expression by using cellular, animal models, and human stomach samples. We found that addition of TNF-α, IL-6, and IL-1β into the culture of ghrelin-producing cell line, MGN3-1 cells, increased GPR142 mRNA expression levels. Lipopolysaccharide (LPS) injection to mice significantly increased GPR142 expression in the stomach, confirming the results observed in the cellular model. GPR142 mRNA expression levels in the stomach samples of morbidly obese patients were positively correlated with TNF-α, IL-6, and IL-1β mRNA levels. Taken together our results suggest that GPR142 expression is under the direct control of proinflammatory cytokines and support further investigation of GPR142 potential roles in inflammation.</p>\",\"PeriodicalId\":12187,\"journal\":{\"name\":\"FEBS Open Bio\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEBS Open Bio\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1002/2211-5463.13973\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEBS Open Bio","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/2211-5463.13973","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Tryptophan-sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin-producing cells.
GPR142 is a tryptophan-sensing receptor that has been implicated in the regulation of inflammation. In this study, we investigated the relationships between inflammatory cytokine and GPR142 expression by using cellular, animal models, and human stomach samples. We found that addition of TNF-α, IL-6, and IL-1β into the culture of ghrelin-producing cell line, MGN3-1 cells, increased GPR142 mRNA expression levels. Lipopolysaccharide (LPS) injection to mice significantly increased GPR142 expression in the stomach, confirming the results observed in the cellular model. GPR142 mRNA expression levels in the stomach samples of morbidly obese patients were positively correlated with TNF-α, IL-6, and IL-1β mRNA levels. Taken together our results suggest that GPR142 expression is under the direct control of proinflammatory cytokines and support further investigation of GPR142 potential roles in inflammation.
期刊介绍：
FEBS Open Bio is an online-only open access journal for the rapid publication of research articles in molecular and cellular life sciences in both health and disease. The journal''s peer review process focuses on the technical soundness of papers, leaving the assessment of their impact and importance to the scientific community.
FEBS Open Bio is owned by the Federation of European Biochemical Societies (FEBS), a not-for-profit organization, and is published on behalf of FEBS by FEBS Press and Wiley. Any income from the journal will be used to support scientists through fellowships, courses, travel grants, prizes and other FEBS initiatives.
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