Guanglei Li, Zengping Lin, Weiqi Bao, Shize Jiang, Jie Wang, Qi Huang, Yang Yang, Juanjuan He, Yiyun Huang, Yihui Guan, Jie Hu, Fang Xie
{"title":"[18F]FDG、[18F]FMZ、[18F]SynVesT-1正电子发射断层成像在耐药癫痫患者中的头部比较","authors":"Guanglei Li, Zengping Lin, Weiqi Bao, Shize Jiang, Jie Wang, Qi Huang, Yang Yang, Juanjuan He, Yiyun Huang, Yihui Guan, Jie Hu, Fang Xie","doi":"10.1007/s00259-025-07111-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The loss of synaptic vesicle glycoprotein 2 A (SV2A) can lead to dysfunction of GABAergic neurons, but a direct comparison of SV2A and GABA<sub>A</sub> receptor densities in humans has not been assessed. This study evaluated SV2A and GABA<sub>A</sub> receptor abnormalities in patients with drug-resistant epilepsy (DRE) and compared the patterns to glucose hypometabolism.</p><p><strong>Methods: </strong>Eleven patients with DRE were retrospectively recruited and underwent PET imaging with [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG), [<sup>18</sup>F]Flumazenil (FMZ), and [<sup>18</sup>F]SynVesT-1. Visual assessments counted abnormal metabolic brain regions based on the Anatomical Automatic Labeling (AAL) atlas, while voxel-level analyses delineated the abnormal metabolic distributions. The relationship between hypo-metabolic distributions and the age of epilepsy onset was analyzed.</p><p><strong>Results: </strong>The hypometabolic regions in [<sup>18</sup>F]FDG PET, identified in the AAL atlas, was significantly broader than in [<sup>18</sup>F]FMZ (p = 0.0005) and [<sup>18</sup>F]SynVesT-1 (p = 0.0010) PET, with no statistical difference observed between [<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET (p > 0.05). The voxel number in [<sup>18</sup>F]FDG PET was significantly higher than that of the [<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET in both hypo-intensity area and severe hypo-intensity area. The ratio of the voxel number between these two area was higher for [<sup>18</sup>F]SynVesT-1 PET compared to [<sup>18</sup>F]FDG PET (p = 0.0195) and [<sup>18</sup>F]FMZ PET (p = 0.0237), and positively correlated with the age of epilepsy onset (r = 0.7397, p = 0.0145).</p><p><strong>Conclusions: </strong>[<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET images revealed a more restricted pattern of reduced uptake compared to [<sup>18</sup>F]FDG PET in DRE patients. The age of epilepsy onset correlated with a reduction in [<sup>18</sup>F]SynVesT-1 uptake but not in [<sup>18</sup>F]FMZ or [<sup>18</sup>F]FDG uptake.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"2258-2266"},"PeriodicalIF":8.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Head-to-Head comparison of [<sup>18</sup>F]FDG, [<sup>18</sup>F]FMZ, and [<sup>18</sup>F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy.\",\"authors\":\"Guanglei Li, Zengping Lin, Weiqi Bao, Shize Jiang, Jie Wang, Qi Huang, Yang Yang, Juanjuan He, Yiyun Huang, Yihui Guan, Jie Hu, Fang Xie\",\"doi\":\"10.1007/s00259-025-07111-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The loss of synaptic vesicle glycoprotein 2 A (SV2A) can lead to dysfunction of GABAergic neurons, but a direct comparison of SV2A and GABA<sub>A</sub> receptor densities in humans has not been assessed. This study evaluated SV2A and GABA<sub>A</sub> receptor abnormalities in patients with drug-resistant epilepsy (DRE) and compared the patterns to glucose hypometabolism.</p><p><strong>Methods: </strong>Eleven patients with DRE were retrospectively recruited and underwent PET imaging with [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG), [<sup>18</sup>F]Flumazenil (FMZ), and [<sup>18</sup>F]SynVesT-1. Visual assessments counted abnormal metabolic brain regions based on the Anatomical Automatic Labeling (AAL) atlas, while voxel-level analyses delineated the abnormal metabolic distributions. The relationship between hypo-metabolic distributions and the age of epilepsy onset was analyzed.</p><p><strong>Results: </strong>The hypometabolic regions in [<sup>18</sup>F]FDG PET, identified in the AAL atlas, was significantly broader than in [<sup>18</sup>F]FMZ (p = 0.0005) and [<sup>18</sup>F]SynVesT-1 (p = 0.0010) PET, with no statistical difference observed between [<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET (p > 0.05). The voxel number in [<sup>18</sup>F]FDG PET was significantly higher than that of the [<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET in both hypo-intensity area and severe hypo-intensity area. The ratio of the voxel number between these two area was higher for [<sup>18</sup>F]SynVesT-1 PET compared to [<sup>18</sup>F]FDG PET (p = 0.0195) and [<sup>18</sup>F]FMZ PET (p = 0.0237), and positively correlated with the age of epilepsy onset (r = 0.7397, p = 0.0145).</p><p><strong>Conclusions: </strong>[<sup>18</sup>F]FMZ and [<sup>18</sup>F]SynVesT-1 PET images revealed a more restricted pattern of reduced uptake compared to [<sup>18</sup>F]FDG PET in DRE patients. The age of epilepsy onset correlated with a reduction in [<sup>18</sup>F]SynVesT-1 uptake but not in [<sup>18</sup>F]FMZ or [<sup>18</sup>F]FDG uptake.</p>\",\"PeriodicalId\":11909,\"journal\":{\"name\":\"European Journal of Nuclear Medicine and Molecular Imaging\",\"volume\":\" \",\"pages\":\"2258-2266\"},\"PeriodicalIF\":8.6000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Nuclear Medicine and Molecular Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00259-025-07111-7\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nuclear Medicine and Molecular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00259-025-07111-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Head-to-Head comparison of [18F]FDG, [18F]FMZ, and [18F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy.
Purpose: The loss of synaptic vesicle glycoprotein 2 A (SV2A) can lead to dysfunction of GABAergic neurons, but a direct comparison of SV2A and GABAA receptor densities in humans has not been assessed. This study evaluated SV2A and GABAA receptor abnormalities in patients with drug-resistant epilepsy (DRE) and compared the patterns to glucose hypometabolism.
Methods: Eleven patients with DRE were retrospectively recruited and underwent PET imaging with [18F]fluorodeoxyglucose ([18F]FDG), [18F]Flumazenil (FMZ), and [18F]SynVesT-1. Visual assessments counted abnormal metabolic brain regions based on the Anatomical Automatic Labeling (AAL) atlas, while voxel-level analyses delineated the abnormal metabolic distributions. The relationship between hypo-metabolic distributions and the age of epilepsy onset was analyzed.
Results: The hypometabolic regions in [18F]FDG PET, identified in the AAL atlas, was significantly broader than in [18F]FMZ (p = 0.0005) and [18F]SynVesT-1 (p = 0.0010) PET, with no statistical difference observed between [18F]FMZ and [18F]SynVesT-1 PET (p > 0.05). The voxel number in [18F]FDG PET was significantly higher than that of the [18F]FMZ and [18F]SynVesT-1 PET in both hypo-intensity area and severe hypo-intensity area. The ratio of the voxel number between these two area was higher for [18F]SynVesT-1 PET compared to [18F]FDG PET (p = 0.0195) and [18F]FMZ PET (p = 0.0237), and positively correlated with the age of epilepsy onset (r = 0.7397, p = 0.0145).
Conclusions: [18F]FMZ and [18F]SynVesT-1 PET images revealed a more restricted pattern of reduced uptake compared to [18F]FDG PET in DRE patients. The age of epilepsy onset correlated with a reduction in [18F]SynVesT-1 uptake but not in [18F]FMZ or [18F]FDG uptake.
期刊介绍：
The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.
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