三磷酸腺苷对哌甲酯诱导的大鼠氧化性和炎症性肾损伤的影响。

IF 2.1 4区 医学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Bahtinur Yeter, Zeynep Suleyman, Seval Bulut, Betul Cicek, Taha Abdulkadir Coban, Ozlem Demir, Halis Suleyman
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引用次数: 0

摘要

本试验的目的是评估哌甲酯对肾脏组织的影响,并探讨三磷酸腺苷(ATP)对哌甲酯肾毒性的保护作用。老鼠被分成两组;健康对照组(HG)、哌醋甲酯(MPHG)、ATP (ATPG)和ATP+哌醋甲酯(AMPG)。ATPG组和AMPG组灌胃ATP 4 mg/kg bw/d, HG组和MPHG组腹腔灌胃蒸馏水。在ATP和蒸馏水给药1 h后,AMPG组和MPHG组分别口服哌甲酯10 mg/kg bw/d,每天1次,连用30 d (1 × 1)。30 d后对动物实施安乐死并收集组织。测定某些氧化/抗氧化参数、促炎细胞因子、血尿素氮(BUN)和肌酐水平。同时对肾脏进行组织病理学检查。ATP抑制哌醋甲酯诱导的氧化水平升高和抗氧化水平降低。与HG和AMPG组相比,哌甲酯处理的肾组织中促炎细胞因子的数量增加。然而,ATP增加氧化损伤标志物和细胞因子水平接近健康组。在ATPG和MPHG组,血清BUN和肌酐水平升高,但ATP阻止BUN和肌酐升高。ATP也能减轻哌甲酯引起的组织病理损伤。ATP治疗哌甲酯所致肾损伤的潜在疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats.

The purpose of this trial was to assess the effects of methylphenidate on the kidney tissues and to investigate the protective effect of adenosine triphosphate (ATP) against possible methylphenidate nephrotoxicity in rats. The rats were separated into; healthy control (HG), methylphenidate (MPHG), ATP (ATPG), and ATP+ methylphenidate (AMPG). The ATPG and AMPG groups were administered ATP 4 mg/kg bw/d, and the HG and MPHG groups received distilled water intraperitoneally. One hour from, ATP and distilled water administration, methylphenidate 10 mg/kg bw/d was applied via oral gavage to the AMPG and MPHG groups once daily for 30 d (1 × 1). Animals were euthanized after 30 d and tissues were collected. The levels of certain oxidant/antioxidant parameters, pro-inflammatory cytokines, and Blood urea nitrogen (BUN) and creatinine levels were measured. Kidneys were also examined histopathologically. ATP inhibited the increase in oxidant and decrease antioxidant levels induced by methylphenidate. The amounts of pro-inflammatory cytokines were increased in methylphenidate-treated kidney tissue compared with the HG and AMPG groups. However, ATP increased oxidative damage markers and cytokines levels close to the healthy group. Serum BUN and creatinine levels increased with methylphenidate but ATP prevented BUN and creatinine from rising in the ATPG and MPHG groups. ATP also reduced the histopathological damage increased by methylphenidate. The potential efficacy of ATP in treating kidney damage induced by methylphenidate use.

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来源期刊
Drug and Chemical Toxicology
Drug and Chemical Toxicology 医学-毒理学
CiteScore
6.00
自引率
3.80%
发文量
99
审稿时长
3 months
期刊介绍: Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.
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