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引用次数: 0
摘要
目的：银屑病与慢性肾脏疾病之间存在显著的炎症相关性和共同的免疫失调特征，但两种疾病的炎症机制尚不清楚。本研究的目的是筛选银屑病和慢性肾脏疾病的免疫相关生物标志物，目的是鉴定特异性分子标志物，以提高疾病诊断的准确性和敏感性。患者和方法：为了实现这一目标，首先确定了牛皮癣和慢性肾脏疾病之间的共同差异表达基因。通过进一步的功能分析，发现这些基因主要参与炎症和先天免疫反应的激活。随后，利用5种拓扑算法确定了6个枢纽基因。这两种疾病的反应在免疫反应上表现出相似的变化。通过将这些关键基因与已知免疫基因交叉分析，鉴定出3个免疫相关枢纽基因（immune related Hub genes, IRHGs），包括MX1、DDX58和ISG20。结果：ROC曲线分析验证了MX1和ISG20在两种疾病中具有良好的鉴别能力。此外，免疫浸润分析显示，牛皮癣和慢性肾脏疾病的样本中T细胞丰度更高，这表明T细胞驱动的免疫反应可能在这两种疾病的关联中起关键作用。最后，单细胞分析分别观察到银屑病和慢性肾病患者T细胞和内皮细胞丰度的显著增加。MX1、DDX58和ISG20在这些细胞中的差异表达提示它们可能不同程度地参与了两种疾病的发病机制。结论：本研究为银屑病和慢性肾脏疾病的预后评估和治疗提供了理论基础，有助于深入了解银屑病和慢性肾脏疾病的免疫机制。
A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.
Purpose: There are significant inflammatory correlations and common immune dysregulation features between psoriasis and chronic kidney disease, however, the inflammatory mechanisms of these two diseases have not been clarified. The aim of this study was to screen immunologically related biomarkers for psoriasis and chronic kidney disease with the objective of identifying specific molecular markers to improve the accuracy and sensitivity of disease diagnosis.
Patients and methods: To achieve this objective, common differentially expressed genes between psoriasis and chronic kidney disease were first identified. Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. Subsequently, six hub genes were determined using five topological algorithms. The responses of these two diseases exhibited similar changes in immune reactions. By cross-analyzing these key genes with known immune genes, three Immunity-Related Hub Genes (IRHGs) were identified, including MX1, DDX58, and ISG20.
Results: ROC curve analysis validated the excellent discriminative ability of MX1 and ISG20 in both diseases. Furthermore, immune infiltration analysis revealed a higher abundance of T cells in samples from both psoriasis and chronic kidney disease, suggesting that T cell-driven immune responses may play a crucial role in the association of these two diseases. Lastly, single-cell analysis observed a significant increase in the cell abundance of T cells and endothelial cells in psoriasis and chronic kidney disease, respectively. The differential expression of MX1, DDX58, and ISG20 in these cells suggests that they may be involved to varying degrees in the pathogenic mechanisms of the two diseases.
Conclusion: This study provides a theoretical foundation for prognosis assessment and treatment of psoriasis and chronic kidney disease, contributing to a deeper understanding of the immune mechanisms underlying these conditions.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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