热稳定水溶性三硫化泛硫氨酸及其复合材料的合成与表征。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI:10.1093/bbb/zbaf010

Shoichiro Tomonaga, Hiroaki Ishimaru, Shizuki Misada, Takahiro Isobe, Etsuo Ohshima, Shinji Kitagaki

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引用次数: 0

摘要

本文首次阐明了一种潜在的新型药物三硫化物泛硫胺的合成方法和性质。三硫化泛硫氨酸是第一个既具有热稳定性又具有水溶性的超硫化合物。它的吸湿性和潮解性促进了三硫化物的水解，但三硫化物泛硫氨酸与硅胶或乳糖的粉末复合材料可以克服这些限制。

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Synthesis and characterization of thermally stable and water-soluble pantetheine trisulfide and its composites.

We clarified for the first time the synthesis procedure and characterization of pantetheine trisulfide, a potential new drug. Pantetheine trisulfide is the first supersulfur compound with both thermal stability and water solubility. Its hygroscopicity and deliquescence promote the hydrolysis of trisulfide, but these limitations are overcome by powdered composites of pantetheine trisulfide with silica gel or lactose.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).