四氢异喹啉生物碱的解析与生物合成：最新进展与展望。

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2025-01-28 DOI:10.1016/j.biotechadv.2025.108524

Yue Gao , Fei Li , Zhenbo Yuan , Zhengshan Luo , Yijian Rao

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引用次数: 0

摘要

四氢异喹啉生物碱（THIAs）是一类重要的植物源化合物，具有多种重要的药用价值。由于THIAs天然生物合成途径的阐明和关键酶的发现，THIAs在微生物中的生物合成取得了相当大的进展。本文就THIAs天然合成途径及其在工业微生物中的生物合成研究进展作一综述。此外，重点介绍了通过构建人工多酶级联和化学酶级联合成THIAs的最新进展。最后，讨论了目前在开发高效的细胞工厂以生产THIAs方面所面临的挑战，以及旨在为THIAs的工业生产提供见解的拟议策略。

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Elucidation and biosynthesis of tetrahydroisoquinoline alkaloids: Recent advances and prospects

Tetrahydroisoquinoline alkaloids (THIAs) are a prominent class of plant-derived compounds with various important pharmaceutical applications. Considerable progress has been made in the biosynthesis of THIAs in microorganisms due to the elucidation of their natural biosynthetic pathways and the discovery of key enzymes. In this review, we systematically summarize recent progress in elucidating the natural biosynthetic pathways of THIAs and their biosynthesis in industrial microorganisms. In addition, recent advancements in the synthesis of THIAs through the construction of artificial multi-enzyme cascades and chemoenzymatic cascades are highlighted. Finally, the current challenges in developing efficient cell factories for producing THIAs are discussed, along with proposed strategies aimed at providing insights into the industrial production of THIAs.

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.