抗tau蛋白过度磷酸化诱导聚集体的天然产物:阿尔茨海默病的潜在疗法。

IF 4.3 3区 医学 Q2 CHEMISTRY, MEDICINAL
Gustavo Basurto-Islas, Maximiliano Caye Diaz, Lizeth M. Zavala Ocampo, Melchor Martínez-Herrera, Perla Y. López-Camacho
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种进行性神经退行性疾病,以认知能力下降和记忆障碍为特征,被认为是最常见的痴呆形式。导致AD的因素之一是微管相关蛋白tau的过度磷酸化。磷酸化的tau降低了其对微管的亲和力,并触发其他翻译后修饰,导致其聚集和组装成细丝。这些结构逐渐积聚在神经元内,导致神经变性。虽然目前的阿尔茨海默病药物通常有不良的副作用,但探索天然产物作为潜在的治疗替代方案已经引起了相当大的关注。许多化合物已经显示出通过不同机制减少tau病理的潜在能力,例如抑制激酶以减少tau过度磷酸化,增强磷酸酶活性和阻断原纤维形成。由于tau过度磷酸化诱导的聚集是AD发病的关键,本综述旨在阐明天然产物在调节这一关键分子机制中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural products against tau hyperphosphorylation-induced aggregates: Potential therapies for Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairments and is considered the most prevalent form of dementia. Among the contributing factors to AD lies the hyperphosphorylation of the microtubule-associated protein tau. Phosphorylated tau reduces its affinity for microtubules and triggers other posttranslational modifications that result in its aggregation and assembly into filaments. These structures progressively accumulate within neurons leading to neurodegeneration. While current AD medications often involve undesirable side effects, the exploration of natural products as a potential therapeutic alternative has gained considerable attention. Numerous compounds have shown potential capacity for reducing tau pathology through different mechanisms, such as inhibiting kinases to reduce tau hyperphosphorylation, enhancing phosphatase activity, and blocking fibril formation. Since tau hyperphosphorylation-induced aggregation is pivotal in AD onset, this review aims to elucidate the potential of natural products in modulating this crucial molecular mechanism.

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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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