1990年至2021年全球、区域和国家老年抑郁症负担和趋势：对2021年全球疾病负担研究的系统分析

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-01-13 DOI:10.1016/j.archger.2025.105758

Quan Sun , Yulong Wei , Hongting Xie , Jiaxuan Lyu , Jingpei Zhou , Xinyu Li , Wanqing Peng , Renhui Zhao , Ziyuan Li , Zhenhu Chen , Jun Lyu , Nanbu Wang

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引用次数: 0

摘要

背景：晚年抑郁症（LLD）是一个日益受到全球公共卫生关注的问题。本研究旨在利用综合数据评估世界范围内的LLD负担。方法：利用全球疾病负担研究的最新证据，我们分析了1990年至2021年LLD负担的趋势，包括发病率、患病率和残疾调整生命年（DALYs）。我们量化了LLD负担在社会经济、性别、地区和国家维度上的差异。采用分解分析方法，找出LLD负荷变化的关键驱动因素。前沿分析说明了各国减轻负担的潜力。结果：2021年，全球有49,137,544例新发病例，46,672,175例流行病例和7,351,377例因LLD导致的残疾。1990年至2021年间，LLD的年龄标准化发病率（ASIR）、年龄标准化患病率（ASPR）和年龄标准化DALYs率（ASDR）均有所上升。2021年，低SDI地区的所有asr最高，而中等SDI地区的这些指标增长率最快。从区域来看，撒哈拉以南非洲中部和东部分别具有最高的ASIR、ASPR和ASDR。在全国范围内，乌干达在2021年的所有asr中排名最高。女性的负担高于男性。人口增长是具有最大改善潜力的中等SDI地区DALYs增长的主要驱动因素。结论：LLD的全球负担已经上升，在SDI、性别、地区和国家之间存在明显的不平等。这种负担在低和中等SDI地区最为明显。这些发现为相关国家（特别是乌干达）制定LLD筛查指南和加强预防和干预战略提供了指导。

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The global, regional, and national late-life depression burden and trends from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021

Background

Late-life depression (LLD) represents a growing global public health concern. This study aimed to assess the worldwide burden of LLD using comprehensive data.

Methods

Leveraging the latest evidence from the Global Burden of Disease Study, we analyzed trends in LLD burden from 1990 to 2021, encompassing incidence, prevalence, and disability-adjusted life years (DALYs). We quantified disparities in LLD burden across socioeconomic, gender, regional, and national dimensions. Decomposition analysis was employed to identify key drivers of LLD burden variation. Frontier analysis illustrated the potential for burden reduction in various countries.

Results

Globally, there were 49,137,544 new cases, 46,672,175 prevalent cases, and 7,351,377 DALYs attributed to LLD in 2021. Between 1990 and 2021, the agestandardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), and age-standardised DALYs rate (ASDR) of LLD all rose. In 2021, low SDI regions exhibited the highest all ASRs, while middle SDI regions had the fastest growth rates in these indicators. Regionally, Central and Eastern Sub-Saharan Africa had the highest ASIR, ASPR, and ASDR, respectively. Nationally, Uganda ranked highest in all ASRs in 2021. Women had higher burdens than men. Population growth was a primary driver of DALYs increase in middle SDI regions that had the greatest potential for improvement.

Conclusions

The global burden of LLD has risen, with marked inequities across SDI, gender, region, and country. The burden is most pronounced in low and middle SDI regions. These findings offer guidance for developing LLD screening guidelines and enhancing prevention and intervention strategies in relevant countries, particularly Uganda.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.