阿尔及利亚西部23例儿童脑静脉血栓形成的临床、病因学、影像学特征和结局。

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2025-02-01 DOI:10.1016/j.arcped.2024.08.010

Zakaria Zoheir Addou , Soumia Benilha , Dalila Boumendil , Kamel El Halimi

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引用次数: 0

摘要

背景：脑静脉血栓形成（CVT）是一种罕见的儿童疾病，其描述在北非仍然有限。我们研究的目的是描述阿尔及利亚西部CVT儿童的临床、病因、放射学、治疗和进化特征。方法：对CVT患儿进行回顾性观察性研究。该研究于2012年1月至2022年12月在加纳斯泰尔儿童医院重症监护室和奥兰医院中心（阿尔及利亚）儿科重症监护室（PICU）进行。结果：共纳入23例患儿，平均年龄48±57个月。最常见的临床症状是发热（61%）、意识改变（61%）、癫痫发作（56.6%）和头痛（36.8%）。主要危险因素为头颈部感染（36.8%）。血栓形成主要影响横窦（65.2%），其次是上矢状窦（39%）。相关的脑并发症主要包括出血性病变（52%）、脑积水（26%）和静脉缺血性梗死（13%）。总体而言，21%的CVT患儿死亡，而我们队列中34%的患儿预后不良。多因素分析中，脑实质出血(aOR: 16.04；95% CI: 1.28- 2015 .5)，机械通气(aOR: 10.50；95% ci: 1.02-108.6)。结论：由于CVT临床体征的非特异性，并考虑到其危险因素，颅脑显像对确诊和早期有效治疗至关重要，以减少潜在的神经系统后遗症和死亡风险。

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Clinical, etiological, radiological characteristics and outcomes of a cohort of 23 children with cerebral venous thrombosis in western Algeria

Background

Cerebral venous thrombosis (CVT) is a rare condition in children, and its description remains limited in North Africa. The objective of our study was to describe the clinical, etiological, radiological, therapeutic, and evolutionary characteristics of children with CVT in western Algeria.

Methods

This was a retrospective observational study involving children with CVT. The study was conducted at the unit of intensive care of Canastel Children's Hospital and the pediatric intensive care unit (PICU) of Oran Hospital Center (Algeria) from January 2012 to December 2022.

Results

A total of 23 children were included in the study, with an average age of 48±57 months. The most frequent clinical signs were fever (61 %), altered consciousness (61 %), seizures (56.6 %), and headaches (36.8 %). The primary risk factors were head and neck infections (36.8 %). Thrombosis mainly affected the transverse sinus (65.2 %), followed by the superior sagittal sinus (39 %). Associated cerebral complications primarily included hemorrhagic lesions (52 %), hydrocephalus (26 %), and venous ischemic infarction (13 %). Overall, 21 % of children with CVT died while 34 % of our cohort had unfavorable outcomes. Predictors of an unfavorable outcome in multivariate analysis were , parenchymal hemorrhage (aOR: 16.04; 95 % CI: 1.28–201.5), and mechanical ventilation (aOR: 10.50; 95 % CI: 1.02–108.6).

Conclusion

Due to the nonspecific nature of CVT clinical signs and considering the risk factors, it is essential to perform cerebral imaging to confirm the diagnosis and initiate early and effective treatment aimed at reducing potential neurological sequelae and the risk of death.

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.