Carl Titusson, Leif Jansson, Carolina Modin, Anna Lundmark, Kaja Eriksson, Lottie Adler, Tülay Yucel-Lindberg
{"title":"牙周和种植体周围健康和疾病中的唾液炎症介质概况：一项横断面研究。","authors":"Carl Titusson, Leif Jansson, Carolina Modin, Anna Lundmark, Kaja Eriksson, Lottie Adler, Tülay Yucel-Lindberg","doi":"10.1111/cid.70002","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This cross-sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri-implant disease as compared to individuals with periodontal and peri-implant health.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising individuals with periodontal and peri-implant health (<i>N</i> = 41), gingivitis and/or mucositis (<i>N</i> = 18), and periodontitis and/or peri-implantitis (<i>N</i> = 96). Samples were analyzed using multiplex-immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The levels of B-cell activating factor (BAFF), sIL-6Rβ, IFN-β, and sIL-6Rα, sTNFR1, and Pentraxin-3 were significantly higher in patients with periodontitis and/or peri-implantitis compared to healthy subjects. Furthermore, among the investigated inflammatory mediators, Pentraxin-3 exhibited the highest diagnostic potential (AUC = 0.74) for distinguishing between subjects with periodontitis and/or peri-implantitis and healthy individuals.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our findings demonstrated elevated salivary levels of BAFF, sIL-6Rβ, IFN-β, sIL-6Rα, sTNF-R1, and Pentraxin-3 in individuals with periodontitis and/or peri-implantitis in comparison to periodontal and peri-implant healthy controls.</p>\n </section>\n </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775428/pdf/","citationCount":"0","resultStr":"{\"title\":\"Salivary Inflammatory Mediator Profiles in Periodontal and Peri-Implant Health and Disease: A Cross-Sectional Study\",\"authors\":\"Carl Titusson, Leif Jansson, Carolina Modin, Anna Lundmark, Kaja Eriksson, Lottie Adler, Tülay Yucel-Lindberg\",\"doi\":\"10.1111/cid.70002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This cross-sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri-implant disease as compared to individuals with periodontal and peri-implant health.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising individuals with periodontal and peri-implant health (<i>N</i> = 41), gingivitis and/or mucositis (<i>N</i> = 18), and periodontitis and/or peri-implantitis (<i>N</i> = 96). Samples were analyzed using multiplex-immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The levels of B-cell activating factor (BAFF), sIL-6Rβ, IFN-β, and sIL-6Rα, sTNFR1, and Pentraxin-3 were significantly higher in patients with periodontitis and/or peri-implantitis compared to healthy subjects. 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Salivary Inflammatory Mediator Profiles in Periodontal and Peri-Implant Health and Disease: A Cross-Sectional Study
Objective
This cross-sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri-implant disease as compared to individuals with periodontal and peri-implant health.
Materials and Methods
Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising individuals with periodontal and peri-implant health (N = 41), gingivitis and/or mucositis (N = 18), and periodontitis and/or peri-implantitis (N = 96). Samples were analyzed using multiplex-immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.
Results
The levels of B-cell activating factor (BAFF), sIL-6Rβ, IFN-β, and sIL-6Rα, sTNFR1, and Pentraxin-3 were significantly higher in patients with periodontitis and/or peri-implantitis compared to healthy subjects. Furthermore, among the investigated inflammatory mediators, Pentraxin-3 exhibited the highest diagnostic potential (AUC = 0.74) for distinguishing between subjects with periodontitis and/or peri-implantitis and healthy individuals.
Conclusions
Our findings demonstrated elevated salivary levels of BAFF, sIL-6Rβ, IFN-β, sIL-6Rα, sTNF-R1, and Pentraxin-3 in individuals with periodontitis and/or peri-implantitis in comparison to periodontal and peri-implant healthy controls.
期刊介绍：
The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal.
The range of topics covered by the journals will include but be not limited to:
New scientific developments relating to bone
Implant surfaces and their relationship to the surrounding tissues
Computer aided implant designs
Computer aided prosthetic designs
Immediate implant loading
Immediate implant placement
Materials relating to bone induction and conduction
New surgical methods relating to implant placement
New materials and methods relating to implant restorations
Methods for determining implant stability
A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.
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