在疑似克罗恩病患者中,血浆和血清钙保护蛋白的诊断准确性低于c反应蛋白。

IF 1.6 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
M H Rasmussen, J B Brodersen, C L Brasen, J S Madsen, T Knudsen, J Kjeldsen, M D Jensen
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引用次数: 0

摘要

背景与目的:已有研究表明血清钙保护蛋白(SC)和血浆钙保护蛋白(PC)可作为克罗恩病(CD)的生物标志物。本研究的目的是探讨SC和PC在临床疑似CD患者中的诊断准确性。方法:该生物库研究纳入了一项前瞻性、盲法、多中心研究,研究了诊断CD的微创方法。患者在2周内进行了标准化的检查,包括回肠结肠镜检查、泛肠胶囊内窥镜检查和血液样本。血浆和血清保存在- 80°C,等待进一步分析。同日检测常规c反应蛋白(CRP)。以泛内窥镜检查为参考标准。结果:126例患者进入研究,58例(46.0%)被诊断为CD。CD患者的中位PC为0.37 mg/L (IQR 0.20-0.70),而非CD患者的中位PC为0.29 mg/L (IQR 0.16-0.41) (p = 0.03)。中位SC分别为1.09 mg/L (IQR 0.80 ~ 1.80)和0.93 mg/L (IQR 0.66 ~ 1.25) (p = 0.01)。患者工作特征曲线显示,SC检测CD的AUC为0.63 (CI 0.53-0.73), PC检测CD的AUC为0.61 (CI 0.51-0.71),低于CRP (AUC = 0.76, CI 0.68-0.85) (p结论:尽管CD患者的PC和SC水平升高,但诊断准确性低于CRP。SC和PC作为诊断CD和选择患者进行内窥镜检查的独立血液生物标志物并不可靠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The diagnostic accuracy of plasma and serum calprotectin is inferior to C-reactive protein in patients with suspected Crohn's disease.

Background and aims: Prior studies indicate that serum calprotectin (SC) and plasma calprotectin (PC) can be used as biomarkers in Crohn's disease (CD). The aim of this study was to investigate the diagnostic accuracy of SC and PC in patients with a clinical suspicion of CD.

Method: This biobank study included patients from a prospective, blinded, multicenter study examining minimally invasive modalities for diagnosing CD. Patients had a standardized work-up including ileocolonoscopy, pan-enteric capsule endoscopy, and blood samples within a 2-week period. Plasma and serum were stored at - 80 °C until further analysis. A routine C-reactive protein (CRP) was measured on the same day. Pan-endoscopy served as reference standard.

Results: 126 patients entered the study, and 58 (46.0%) were diagnosed with CD. Patients with CD had a median PC of 0.37 mg/L (IQR 0.20-0.70) compared to 0.29 mg/L (IQR 0.16-0.41) in non-CD patients (p = 0.03). The median SC was 1.09 mg/L (IQR 0.80-1.80) and 0.93 mg/L (IQR 0.66-1.25), respectively (p = 0.01). Receiver operating characteristics curves showed an AUC of 0.63 (CI 0.53-0.73) for SC and 0.61 (CI 0.51-0.71) for PC for detection of CD, which was inferior to that of CRP (AUC = 0.76, CI 0.68-0.85) (p < 0.02). None of the biomarkers reflected the endoscopic severity of CD.

Conclusion: Although levels of PC and SC are elevated in patients with CD, diagnostic accuracies are inferior to CRP. SC and PC are not reliable as stand-alone blood-based biomarkers for diagnosing CD and selecting patients for endoscopy.

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来源期刊
CiteScore
3.40
自引率
5.30%
发文量
222
审稿时长
3-8 weeks
期刊介绍: The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution
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