Jatamansi Taila Shirodhara对三阴性乳腺癌（TNBC）患者心理困扰的精神放松效果-一项开放标签，随机对照临床试验的结果。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine Pub Date : 2025-01-01 DOI:10.1016/j.jaim.2024.101069

Sadanand Sardeshmukh , Vineeta Deshmukh , Vasanti Godse , Anaya Pathrikar , Abhijeet Joshi , Shweta Gujar , Bhagyashri Sardeshmukh , Anjali Deshpande , Sushama Bhuvad

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引用次数: 0

摘要

背景：三阴性乳腺癌（TNBC）是临床上定义为雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体（HER2）缺乏表达的乳腺癌亚型。心理困扰是TNBC的主要危险因素，由于疾病的侵袭性，被诊断为TNBC的患者承受着巨大的压力。应激激素会降低治疗的效果。这些事实强调了对TNBC患者进行精神放松治疗的必要性。目的：了解三阴癌患者的抗焦虑作用。材料和方法：这是一项双臂、开放标签、平行、前瞻性对照临床研究，对70名年龄在20-70岁之间的TNBC患者进行了研究，这些患者完成了传统治疗并选择了阿育吠陀治疗。患者分为两组。A组35例患者口服阿育吠陀药物（Shamana Chikitsa）和Jatamansi Taila Shirodhara治疗；而B组35例患者仅接受口服阿育吠陀药物治疗。结果：Jatamansi Taila Shirodhara可有效缓解手术后立即出现的焦虑和心理困扰（Chittodvega）症状，即睡眠障碍、注意力不集中和恐惧。通过QLQ C30评分和QLQ BR23症状评分，发现Jatamansi Taila Shirodhara在改善生活质量（QoL）方面非常有效，特别是在改善功能能力、幸福感和减少与乳腺癌相关的症状方面。结论：本研究强调了Jatamansi Taila Shirodhara身心放松疗法在乳腺癌尤其是TNBC患者心理困扰中的作用。

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Mind relaxation effect of Jatamansi Taila Shirodhara on psychological distress in Triple Negative Breast Cancer (TNBC) patients - results of an open-labelled, randomised controlled clinical trial

Background

Triple-negative breast cancer (TNBC) is a subtype of breast cancer clinically defined as lacking expression of Estrogen receptor (ER), Progesterone receptor (PR), and Human Epidermal growth factor Receptor (HER2). Psychological distress is a major risk factor of TNBC, patients diagnosed with TNBC are under tremendous stress due to the aggressive nature of the disease. Stress hormones decrease the efficacy of therapeutics. These facts underscore the need for mind relaxation treatment for TNBC patients.

Objectives

To find out the anti-anxiety activity of the Jatamansi Taila in TNBC patients.

Material and methods

This was a two-arm, open-labelled, parallel, prospective controlled clinical study, conducted on 70 patients of TNBC in the age group of 20–70 years who have completed conventional therapy and opted for Ayurvedic Treatment. Patients were divided into 2 groups. Thirty-five patients in Group A were treated with Oral Ayurvedic Medicines (Shamana Chikitsa) and Jatamansi Taila Shirodhara; whereas 35 patients in Group B were treated with only Oral Ayurvedic Medicines.

Results

Jatamansi Taila Shirodhara was found to be effective in relieving symptoms of Anxiety and Psychological distress (Chittodvega) immediately after the procedure, viz. sleep disturbance, difficulty in concentration, and fearfulness. Jatamansi Taila Shirodhara was found to be highly effective in improving Quality of Life (QoL), especially in improving functional ability, well-being and reducing symptomatology related to breast cancer, measured by scores of QLQ C30 and symptom score of QLQ BR23.

Conclusion

This study emphasizes the role of Jatamansi Taila Shirodhara therapy for mind and body relaxation in psychological distress seen in breast cancer especially, in TNBC patients.

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