P. J. A. van Nuland, J. Halim, D. J. van Ginkel, D. C. Overduin, J. Brouwer, V. J. Nijenhuis, A. W. J. van't Hof, P. A. L. Tonino, J. M. ten Berg, P. A. Vriesendorp
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This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, <i>n</i> = 779), PPI before TAVI (PPI pre-TAVI, <i>n</i> = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>At 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, <i>p</i> = 0.53) and 10.3% (PPI post-TAVI, <i>p</i> = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, <i>p</i> = 0.58) and 6.2% (PPI post-TAVI, <i>p</i> = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (<i>p</i> = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>PPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.</p>\n </section>\n </div>","PeriodicalId":9650,"journal":{"name":"Catheterization and Cardiovascular Interventions","volume":"105 5","pages":"1098-1107"},"PeriodicalIF":2.1000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy\",\"authors\":\"P. J. A. van Nuland, J. Halim, D. J. van Ginkel, D. C. Overduin, J. Brouwer, V. J. Nijenhuis, A. W. J. van't Hof, P. A. L. Tonino, J. M. ten Berg, P. A. Vriesendorp\",\"doi\":\"10.1002/ccd.31431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Conduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). 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引用次数: 0
摘要
背景：经导管主动脉瓣植入术（TAVI）后传导障碍很常见，通常需要永久性起搏器植入术（PPI）。关于其对死亡率和发病率影响的数据相互矛盾。本研究旨在评估TAVI术前或术后30天内PPI对TAVI术后一年内死亡率和健康相关生活质量（QoL）的影响。方法：在这项POPular TAVI亚研究中，纳入978例患者，分为三组：TAVI前或后30天内未PPI (n = 779)， TAVI前未PPI (n = 102)， TAVI后30天内PPI （n = 97）。1年时评估全因死亡和心源性死亡。在基线和3、6和12个月时使用SF-12和EQ-5D-5L问卷评估生活质量。结果：1年时，全因死亡率分别为6.9% （tavi前PPI， p = 0.53）和10.3% (tavi后PPI， p = 0.66)，而非PPI组的全因死亡率为8.7%。4.9% （tavi前PPI， p = 0.58）和6.2% （tavi后PPI， p = 0.94）的患者发生心源性死亡，而未发生PPI的患者为6.2%。在生活质量方面，tavi前PPI组的PCS-12随时间的推移低于未PPI组（p = 0.04），而MCS-12、EQ-5D指数和EQ-5D VAS评分相等。tavi后PPI组与未PPI组的生活质量无显著差异。结论：TAVI术前或术后30天内PPI与1年内死亡率升高无关。tavi前PPI与较低的物理生活质量相关。
The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy
Background
Conduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.
Methods
In this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.
Results
At 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.
Conclusion
PPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.
期刊介绍：
Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.
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