ABT，埃拉西达和胆管插管大鼠：了解药代动力学的工具。

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-01-28 DOI:10.1002/cmdc.202400995

Gilles Ouvry

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引用次数: 0

摘要

优化药代动力学是药物设计的一个组成部分，尽管从药物化学家的角度来看，这是一个鲜为人知的部分。多年来，为了更好地了解化合物的命运，人们开发了分子工具和实验策略。其中，氨基苯并三唑（ABT）、埃拉西达（elacridar）和胆管插管大鼠的使用有助于获得有价值的PK见解，对药物设计有直接影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ABT, Elacridar and Bile-Duct Cannulated Rats: Tools to Understand Pharmacokinetics

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ABT, Elacridar and Bile-Duct Cannulated Rats: Tools to Understand Pharmacokinetics

Optimizing pharmacokinetics is an integral part of drug design, albeit a lesser understood one from the medicinal chemist's perspective. Over the years, molecular tools and experimental strategies have been developed to better understand the fate of compounds. Among these, the use of aminobenzotriazole (ABT), elacridar and bile-duct cannulated rats have been instrumental in gaining valuable PK insights, with a direct impact on drug design.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.