生物纳米医学在癌症治疗中的分子成像:当前的见解和挑战

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Wenzhu Hu, Mengting Li, Yuan Feng, Xingyi Wang, Shaowen Yang, Yu Gao, Dawei Jiang, Xiaoli Lan
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引用次数: 0

摘要

将生物膜涂覆在仿生纳米载体上,提高了生物相容性,延长了血液循环,增强了癌症精准医疗的靶向递送。为了更好地了解这些仿生纳米系统的生物分布特征,分子成像技术,包括光学成像、放射性核素成像、磁共振成像和超声成像,已被广泛用于体内跟踪和动态成像。在这篇综述中,我们深入探讨了这些成像方式在可视化肿瘤微环境变化中的深远作用,特别是在监测氧气消耗和免疫反应动力学方面,强调了它们改善癌症治疗的潜力。我们还简要讨论了分子成像在协同癌症治疗中的应用现状和未来的展望。最后,我们提供了整合仿生纳米医学与分子成像临床翻译的潜力的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular Imaging for Biomimetic Nanomedicine in Cancer Therapy: Current Insights and Challenges

Molecular Imaging for Biomimetic Nanomedicine in Cancer Therapy: Current Insights and Challenges
Coating biological membranes onto biomimetic nanocarriers improves biocompatibility, prolongs circulation, and enhances targeted delivery for cancer precision medicine. To better understand the biodistribution profiles of these biomimetic nanosystems, molecular imaging techniques, including optical imaging, radionuclide imaging, magnetic resonance imaging, and ultrasound imaging, have been widely employed for in vivo tracking and dynamic imaging. Here in this review, we delve into the profound role of these imaging modalities in visualizing changes in the tumor microenvironment, particularly in monitoring oxygen consumption and immune response dynamics, highlighting their potential to improve cancer therapies. We also briefly discuss current applications of molecular imaging in synergistic cancer therapies and future perspectives. Finally, we offer insights into the potential of integrating biomimetic nanomedicine with molecular imaging for clinical translation.
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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