Prodromos Gavriilidis, Felix M. Mottaghy, Michel Koole, Tineke van de Weijer, Cristina Mitea, Jochem A. J. van der Pol, Thiemo J. A. van Nijnatten, Floris P. Jansen, Roel Wierts
{"title":"Impact of tissue-independent positron range correction on [68Ga]Ga-DOTATOC and [68Ga]Ga-PSMA PET image reconstructions: a patient data study","authors":"Prodromos Gavriilidis, Felix M. Mottaghy, Michel Koole, Tineke van de Weijer, Cristina Mitea, Jochem A. J. van der Pol, Thiemo J. A. van Nijnatten, Floris P. Jansen, Roel Wierts","doi":"10.1007/s00259-024-07061-6","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The positron range effect can impair PET image quality of Gallium-68 (<sup>68</sup>Ga). A positron range correction (PRC) can be applied to reduce this effect. In this study, the effect of a tissue-independent PRC for <sup>68</sup>Ga was investigated on patient data.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>PET/CT data (40 patients: [<sup>68</sup>Ga]Ga-DOTATOC or [<sup>68</sup>Ga]Ga-PSMA) were reconstructed using Q.Clear reconstruction algorithm. Two reconstructions were performed per patient, Q.Clear with and without PRC. SUV<sub>max</sub> and contrast-to-noise ratio (CNR) values per lesion were compared between PRC and non-PRC images. Five experienced nuclear medicine physicians reviewed the images and chose the preferred reconstruction based on the image quality, lesion detectability, and diagnostic confidence.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 155 lesions were identified. The PRC resulted in statistically significant increase of the SUV<sub>max</sub> and CNR for soft tissue lesions (6.4%, p < 0.001; 8.6%, p < 0.001), bone lesions (14.6%, p < 0.001; 12.5%, p < 0.001), and lung lesions (3.6%, p = 0.010; 6.3%, p = 0.001). This effect was most prominent in small lesions (SUV<sub>max</sub>: 12.0%, p < 0.001, and CNR: 13.0%, p < 0.001). Similar or better image quality, lesion detectability, and diagnostic confidence was achieved in PRC images compared to the non-PRC images as those assessed by the expert readers.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>A tissue-independent PRC increased the SUV<sub>max</sub> and CNR in soft tissue, bone, and lung lesions with a larger effect for the small lesions. Visual assessment demonstrated similar or better image quality, lesion detectability, and diagnostic confidence in PRC images compared to the non-PRC images.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"40 1","pages":""},"PeriodicalIF":8.6000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nuclear Medicine and Molecular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00259-024-07061-6","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Impact of tissue-independent positron range correction on [68Ga]Ga-DOTATOC and [68Ga]Ga-PSMA PET image reconstructions: a patient data study
Purpose
The positron range effect can impair PET image quality of Gallium-68 (68Ga). A positron range correction (PRC) can be applied to reduce this effect. In this study, the effect of a tissue-independent PRC for 68Ga was investigated on patient data.
Methods
PET/CT data (40 patients: [68Ga]Ga-DOTATOC or [68Ga]Ga-PSMA) were reconstructed using Q.Clear reconstruction algorithm. Two reconstructions were performed per patient, Q.Clear with and without PRC. SUVmax and contrast-to-noise ratio (CNR) values per lesion were compared between PRC and non-PRC images. Five experienced nuclear medicine physicians reviewed the images and chose the preferred reconstruction based on the image quality, lesion detectability, and diagnostic confidence.
Results
A total of 155 lesions were identified. The PRC resulted in statistically significant increase of the SUVmax and CNR for soft tissue lesions (6.4%, p < 0.001; 8.6%, p < 0.001), bone lesions (14.6%, p < 0.001; 12.5%, p < 0.001), and lung lesions (3.6%, p = 0.010; 6.3%, p = 0.001). This effect was most prominent in small lesions (SUVmax: 12.0%, p < 0.001, and CNR: 13.0%, p < 0.001). Similar or better image quality, lesion detectability, and diagnostic confidence was achieved in PRC images compared to the non-PRC images as those assessed by the expert readers.
Conclusions
A tissue-independent PRC increased the SUVmax and CNR in soft tissue, bone, and lung lesions with a larger effect for the small lesions. Visual assessment demonstrated similar or better image quality, lesion detectability, and diagnostic confidence in PRC images compared to the non-PRC images.
期刊介绍：
The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.
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