{"title":"全球DNA疫苗研究热点与趋势：2014 - 2024年文献计量与可视化研究","authors":"Juan Zhang, Haiguo Zhang, Cuicui Yao, Lihua Gu, Shasha Dong, Yamei Wu, Lele Miao","doi":"10.1080/21645515.2025.2457189","DOIUrl":null,"url":null,"abstract":"<p><p>This bibliometric and visualization study provides a comprehensive analysis of global research hotspots and trends in DNA vaccine research from 2014 to 2024. By employing data sourced from the Web of Science Core Collection, we identified a total of 3,600 articles. Our analysis reveals a declining trend in annual publications. Active countries, institutions, journals, and authors were identified, with China, the Pasteur Network, the <i>Vaccine</i> Journal, and David B Weiner being the most prolific contributors. Keywords cluster analysis distinguished four major research directions: infectious disease and immunity, viral challenge and vaccine development, optimization of DNA vaccine delivery systems, and cancer and immunotherapy research. The literature co-citation analysis revealed four major research hotspots, including DNA vaccines for Zika virus, human papillomavirus (HPV), and COVID-19, as well as safety, efficacy, and immunogenicity studies of DNA vaccines. Concurrently, the burst citation analysis identified emerging themes, including the development of DNA vaccines for COVID-19, Ebola, and MERS-CoV, as well as innovations in antigen design and delivery technologies. This study offers valuable insights into the evolution and future directions of DNA vaccine research, emphasizing its importance for global public health and the potential to address current and future health challenges.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2457189"},"PeriodicalIF":4.1000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776459/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global research hotspots and trends in DNA vaccine research: A bibliometric and visualization study from 2014 to 2024.\",\"authors\":\"Juan Zhang, Haiguo Zhang, Cuicui Yao, Lihua Gu, Shasha Dong, Yamei Wu, Lele Miao\",\"doi\":\"10.1080/21645515.2025.2457189\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This bibliometric and visualization study provides a comprehensive analysis of global research hotspots and trends in DNA vaccine research from 2014 to 2024. 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引用次数: 0
摘要
本文献计量和可视化研究全面分析了2014 - 2024年全球DNA疫苗研究热点和趋势。通过使用来自Web of Science核心馆藏的数据，我们确定了总共3600篇文章。我们的分析揭示了年度出版物的下降趋势。确定了活跃的国家、机构、期刊和作者，其中中国、巴斯德网络、疫苗杂志和David B Weiner是最多产的贡献者。关键词聚类分析区分出传染病与免疫、病毒攻击与疫苗开发、DNA疫苗递送系统优化、癌症与免疫治疗研究四大研究方向。文献共引分析揭示了寨卡病毒、人乳头瘤病毒（HPV）和COVID-19 DNA疫苗的四大研究热点，以及DNA疫苗的安全性、有效性和免疫原性研究。与此同时，突发引文分析确定了新兴主题，包括针对COVID-19、埃博拉病毒和中东呼吸综合征冠状病毒的DNA疫苗的开发，以及抗原设计和递送技术的创新。这项研究为DNA疫苗研究的演变和未来方向提供了宝贵的见解，强调了其对全球公共卫生的重要性以及解决当前和未来卫生挑战的潜力。
Global research hotspots and trends in DNA vaccine research: A bibliometric and visualization study from 2014 to 2024.
This bibliometric and visualization study provides a comprehensive analysis of global research hotspots and trends in DNA vaccine research from 2014 to 2024. By employing data sourced from the Web of Science Core Collection, we identified a total of 3,600 articles. Our analysis reveals a declining trend in annual publications. Active countries, institutions, journals, and authors were identified, with China, the Pasteur Network, the Vaccine Journal, and David B Weiner being the most prolific contributors. Keywords cluster analysis distinguished four major research directions: infectious disease and immunity, viral challenge and vaccine development, optimization of DNA vaccine delivery systems, and cancer and immunotherapy research. The literature co-citation analysis revealed four major research hotspots, including DNA vaccines for Zika virus, human papillomavirus (HPV), and COVID-19, as well as safety, efficacy, and immunogenicity studies of DNA vaccines. Concurrently, the burst citation analysis identified emerging themes, including the development of DNA vaccines for COVID-19, Ebola, and MERS-CoV, as well as innovations in antigen design and delivery technologies. This study offers valuable insights into the evolution and future directions of DNA vaccine research, emphasizing its importance for global public health and the potential to address current and future health challenges.
期刊介绍：
(formerly Human Vaccines; issn 1554-8619)
Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics.
Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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