放疗对多灶性乳腺肿瘤发生的矛盾控制。

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2025-12-01 Epub Date: 2025-01-28 DOI:10.1080/2162402X.2025.2458886

Lorenzo Galluzzi, Aitziber Buqué

引用次数: 0

摘要

在一个多灶、异时性HR+乳腺癌的免疫功能小鼠模型中，我们最近证明了局灶放疗对原发性肿瘤病变的优越控制并不一定转化为对非辐照（前）恶性组织的肿瘤抑制。这些数据表明放射治疗局部肿瘤控制与全身性肿瘤发生之间的联系仍有待充分了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Paradoxical control of multifocal mammary oncogenesis by radiation therapy.

查看原文本刊更多论文

Paradoxical control of multifocal mammary oncogenesis by radiation therapy.

In an immunocompetent mouse model of multifocal, metachronous HR⁺ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.