Ulla Aapola, Paula Mosallaei, Janika Nättinen, Ilona Suurkuukka, Jaakko Tuomilehto, Sirkka Keinänen-Kiukaanniemi, Jouko Saramies, Hannu Uusitalo
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Various statistical methods were employed to explore the associations between QoL, ocular surface health, and sex disparities.</p><p><strong>Results: </strong>DED had negative impact on QoL in all participants, and especially in women. Adjusted for comorbidities, DED doubled the odds of worse health-related QoL (15D: OR = 2.31 [95% CI: 1.24-4.31, p < 0.01]) and mental health (SF-36 MCS and BDI-II: OR = 2.08 [95% CI: 1.04-4.16, p < 0.05]). Noninvasive tear break-up time (NIBUT) correlated with all QoL scores. In women, the most significant clinical signs correlating with low QoL were NIBUT (15D: r = 0.20, p = 0.002; SF-36 MCS: r = 0.18, p = 0.026), and conjunctival staining (15D: r=-0.19, p = 0.004; BDI-II: r = 0.27, p < 0.001), whereas in men, blepharitis correlated with depression score (BDI-II: r = 0.20, p = 0.036). High OSDI was associated with worse QoL in women, but not in men.</p><p><strong>Conclusion: </strong>This first population-based study assessing general QoL data with objective clinical measures of DED indicated that among elderly population, both symptoms and signs of DED independently impacted different aspects of QoL. 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引用次数: 0
摘要
目的:评估芬兰人群队列中生活质量(QoL)与眼表健康之间的关系。方法:对1933-1956年间出生的601人进行横断面研究。眼表健康和干眼病(DED)的临床评价采用几种诊断试验。参与者完成眼表疾病指数(OSDI),用15D和医学结局研究36项简短健康调查(SF-36)评估生活质量,以及贝克抑郁量表(BDI-II)问卷。采用各种统计方法探讨生活质量、眼表健康和性别差异之间的关系。结果:DED对所有参与者的生活质量都有负面影响,尤其是女性。经合并症调整后,DED使与健康相关的生活质量恶化的几率增加了一倍(15D: OR = 2.31) [95% CI: 1.24-4.31, p]。结论:这是第一个基于人群的研究,用DED的客观临床测量评估一般生活质量数据,表明在老年人群中,DED的症状和体征都独立影响生活质量的不同方面。此外,在这些关联中观察到显著的性别差异,在研究环境中以及在评估和治疗DED患者时都应考虑到这一点。
Impact of signs and symptoms of dry eye disease on health-related quality of life: a cross-sectional population study among older adults.
Purpose: To assess the relationship between quality of life (QoL) and ocular surface health within a Finnish population-based cohort.
Methods: A cross-sectional study involved 601 individuals born between the years 1933-1956. Ocular surface health and dry eye disease (DED) were clinically evaluated using several diagnostic tests. Participants completed the Ocular Surface Disease Index (OSDI), QoL assessment with the 15D and Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and the Beck's Depression Inventory (BDI-II) questionnaires. Various statistical methods were employed to explore the associations between QoL, ocular surface health, and sex disparities.
Results: DED had negative impact on QoL in all participants, and especially in women. Adjusted for comorbidities, DED doubled the odds of worse health-related QoL (15D: OR = 2.31 [95% CI: 1.24-4.31, p < 0.01]) and mental health (SF-36 MCS and BDI-II: OR = 2.08 [95% CI: 1.04-4.16, p < 0.05]). Noninvasive tear break-up time (NIBUT) correlated with all QoL scores. In women, the most significant clinical signs correlating with low QoL were NIBUT (15D: r = 0.20, p = 0.002; SF-36 MCS: r = 0.18, p = 0.026), and conjunctival staining (15D: r=-0.19, p = 0.004; BDI-II: r = 0.27, p < 0.001), whereas in men, blepharitis correlated with depression score (BDI-II: r = 0.20, p = 0.036). High OSDI was associated with worse QoL in women, but not in men.
Conclusion: This first population-based study assessing general QoL data with objective clinical measures of DED indicated that among elderly population, both symptoms and signs of DED independently impacted different aspects of QoL. In addition, significant sex-differences in these associations were observed and should be considered both in research settings and when assessing and treating people with DED.
期刊介绍:
Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences.
Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership.
This is an official journal of the International Society of Quality of Life Research.