红参对自然衰老小鼠听觉、认知和肝功能的影响。

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2025-01-01 DOI:10.1016/j.jgr.2024.10.001

Sung Woo Shin , Ji Heon Shim , Youn Hee Nam , Na Woo Kim , Gyeong Jin Seo , Murughanantham Nevedita , Pandian Subha , Quy-Hoai Nguyen , Yong Su Jeong , Bin Na Hong , Tong Ho Kang

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引用次数: 0

摘要

背景：韩国红参和人参皂苷已被研究其对各种疾病的功效，包括与衰老有关的疾病。然而，大多数衰老研究使用d -半乳糖诱导衰老，这往往不能准确地代表自然衰老。这项研究旨在通过给18个月大的自然衰老小鼠模型服用红参来验证听觉、认知和肝功能的改善。方法：采用听觉脑干反应（ABR）和听觉中潜伏期反应（AMLR）评价听觉功能。认知功能电生理评价采用P300和失配负性（MMN），行为学评价采用y型迷宫。此外，进行生化试验和组织学分析以评估肝功能。红参对耳蜗、听觉皮层和肝脏基因表达调控的影响也被研究，重点是与年龄相关的疾病过程。结果：红参能明显降低听力阈值，改善中枢听觉功能。它还增强了对外界刺激的认知行为和功能。红参还能调节碱性磷酸酶（ALP）、白蛋白（Alb）和总蛋白（TP）水平，显著降低天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平。肝组织苏木精和伊红（H&E）染色显示脂肪滴明显改善。这些影响似乎是由衰老相关基因Dec、c-Jun、Stat5b和Lims2的调控介导的。结论：红参对自然衰老小鼠的听觉、认知和肝功能有改善作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model

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Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model

Background

Korean Red Ginseng and ginsenosides have been studied for their efficacy against various diseases, including those related to aging. However, most aging studies use D-galactose to induce aging, which often does not accurately represent natural aging. This study aimed to verify improvements in auditory, cognitive, and liver function through administering red ginseng to an 18-month-old naturally aging mouse model.

Methods

Auditory function was assessed using Auditory Brainstem Response (ABR) and Auditory Middle Latency Response (AMLR). Cognitive function was evaluated electrophysiologically with P300 and mismatch negativity (MMN), and behaviorally using the Y-maze. Additionally, biochemical tests and histological analysis were conducted to assess liver function. The effects of red ginseng on gene expression regulation were also examined in the cochlea, auditory cortex, and liver, focusing on age-related disease processes.

Results

Red ginseng significantly decreased hearing thresholds and improved central auditory function. It also enhanced cognitive behavior and function in response to external stimulation. Furthermore, red ginseng regulated alkaline phosphatase (ALP), albumin (Alb), and total protein (TP) levels, notably decreasing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Hematoxylin and eosin (H&E) staining of liver tissue showed significant improvement in fat droplets. These effects appear to be mediated by the regulation of aging-related genes Dec, c-Jun, Stat5b, and Lims2.

Conclusion

These results suggest that red ginseng improves auditory, cognitive, and liver functions in a naturally aged mouse model.

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.