Daniel A de Luis, Olatz Izaola, David Primo Martin, Juan J López-Gómez
{"title":"转录因子7-样2（TCF7L2）基因变异rs7903146对24周代餐低热量饮食的人体测量和代谢反应的影响","authors":"Daniel A de Luis, Olatz Izaola, David Primo Martin, Juan J López-Gómez","doi":"10.1159/000543557","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Some studies have demonstrated the effect of the rs7903146 genetic variant on weight response after different dietary strategies. The objective of our study was to evaluate the role of this genetic variant of the TCF7L2 gene on weight loss and diabetes mellitus progression following a partial meal replacement (pMR) hypocaloric diet.</p><p><strong>Methods: </strong>We conducted an interventional study in 214 subjects with obesity and a body mass index (BMI) >35 kg/m2. The subjects received two servings per day of a normocaloric hyperproteic formula for 24 weeks as part of a pMR diet. Body weight, BMI, fat mass, waist circumference, lipid profile, fasting insulin levels, and HOMA-IR were determined. All patients were genotyped for rs7903146 and evaluated under a dominant model (CC vs. CT + TT).</p><p><strong>Results: </strong>The decrease at 24 weeks was higher in non-T-allele carriers compared to T-allele carriers (BMI: -3.3 ± 0.3 kg/m2 vs. -2.2 ± 0.2 kg/m2; p = 0.02; weight: -9.5 ± 1.1 kg vs. -5.0 ± 1.0 kg; p = 0.01; fat mass: -8.7 ± 0.2 kg vs. -4.0 ± 0.2 kg; p = 0.04; waist circumference: -8.0 ± 0.2 cm vs. -3.0 ± 0.4 cm; p = 0.04; glucose levels: -7.1 ± 1.2 mg/dL vs. -1.2 ± 1.1 mg/dL; p = 0.01; insulin: -10.1 ± 1.1 µIU/L vs. -4.0 ± 1.0 µIU/L; p = 0.01; HOMA-IR: -2.1 ± 1.1 units vs. -0.5 ± 0.1 units; p = 0.01; C-reactive protein: -0.9 ± 0.1 mg/dL vs. -0.4 ± 0.2 mg/dL; p = 0.01; triglycerides: -17.1 ± 0.1 mg/dL vs. -9.1 ± 0.2 mg/dL; p = 0.01; and HbA1c: -1 ± 0.1% vs. -0.3 ± 0.2%; p = 0.01). Following the dietary intervention, only non-T-allele carriers showed a significant decrease in the frequency of hypertriglyceridemia, abdominal waist, hyperglycemia, and DM2.</p><p><strong>Conclusions: </strong>The TCF7L2 (rs7903146) polymorphism modulates pMR diet-induced changes in body weight, lipid metabolism, and insulin resistance. These changes lead to a significant decrease in the prevalence of hyperglycemia and other components of metabolic syndrome.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"141-149"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of the Variant rs7903146 of Transcription Factor 7-Like 2 Gene on Anthropometric and Metabolic Responses to a 24 Weeks Meal Replacement Hypocaloric Diet.\",\"authors\":\"Daniel A de Luis, Olatz Izaola, David Primo Martin, Juan J López-Gómez\",\"doi\":\"10.1159/000543557\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Some studies have demonstrated the effect of the rs7903146 genetic variant on weight response after different dietary strategies. The objective of our study was to evaluate the role of this genetic variant of the TCF7L2 gene on weight loss and diabetes mellitus progression following a partial meal replacement (pMR) hypocaloric diet.</p><p><strong>Methods: </strong>We conducted an interventional study in 214 subjects with obesity and a body mass index (BMI) >35 kg/m2. The subjects received two servings per day of a normocaloric hyperproteic formula for 24 weeks as part of a pMR diet. Body weight, BMI, fat mass, waist circumference, lipid profile, fasting insulin levels, and HOMA-IR were determined. All patients were genotyped for rs7903146 and evaluated under a dominant model (CC vs. CT + TT).</p><p><strong>Results: </strong>The decrease at 24 weeks was higher in non-T-allele carriers compared to T-allele carriers (BMI: -3.3 ± 0.3 kg/m2 vs. -2.2 ± 0.2 kg/m2; p = 0.02; weight: -9.5 ± 1.1 kg vs. -5.0 ± 1.0 kg; p = 0.01; fat mass: -8.7 ± 0.2 kg vs. -4.0 ± 0.2 kg; p = 0.04; waist circumference: -8.0 ± 0.2 cm vs. -3.0 ± 0.4 cm; p = 0.04; glucose levels: -7.1 ± 1.2 mg/dL vs. -1.2 ± 1.1 mg/dL; p = 0.01; insulin: -10.1 ± 1.1 µIU/L vs. -4.0 ± 1.0 µIU/L; p = 0.01; HOMA-IR: -2.1 ± 1.1 units vs. -0.5 ± 0.1 units; p = 0.01; C-reactive protein: -0.9 ± 0.1 mg/dL vs. -0.4 ± 0.2 mg/dL; p = 0.01; triglycerides: -17.1 ± 0.1 mg/dL vs. -9.1 ± 0.2 mg/dL; p = 0.01; and HbA1c: -1 ± 0.1% vs. -0.3 ± 0.2%; p = 0.01). Following the dietary intervention, only non-T-allele carriers showed a significant decrease in the frequency of hypertriglyceridemia, abdominal waist, hyperglycemia, and DM2.</p><p><strong>Conclusions: </strong>The TCF7L2 (rs7903146) polymorphism modulates pMR diet-induced changes in body weight, lipid metabolism, and insulin resistance. 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引用次数: 0
摘要
一些研究已经证实了rs7903146基因变异对不同饮食策略后体重反应的影响。本研究的目的是评估TCF7L2基因的这种遗传变异在部分代餐（pMR）低热量饮食后体重减轻和糖尿病进展中的作用。方法：对214例体重指数（BMI）为35 kg/m²的肥胖患者进行介入研究。作为pMR饮食的一部分，受试者每天接受两份等热量高蛋白配方，持续24周。测定体重、体重指数（BMI）、脂肪量、腰围、脂质谱、空腹胰岛素水平和HOMA-IR。所有患者均进行rs7903146基因分型，并在优势模型（CC vs. CT+TT）下进行评估。结果：与T等位基因携带者相比，非T等位基因携带者在24周时的下降幅度更大(BMI: -3.3±0.3 kg/m²vs -2.2±0.2 kg/m²，p=0.02；重量：-9.5±1.1 kg vs -5.0±1.0 kg, p=0.01；脂肪质量：-8.7±0.2 kg vs -4.0±0.2 kg, p=0.04；腰围：-8.0±0.2 cm vs. -3.0±0.4 cm, p=0.04；血糖水平：-7.1±1.2 mg/dL vs -1.2±1.1 mg/dL, p=0.01；胰岛素:-10.1±1.1µIU / L和-4.0±1.0µIU / L, p = 0.01;HOMA-IR: -2.1±1.1单位vs -0.5±0.1单位，p=0.01；c反应蛋白：-0.9±0.1 mg/dL vs. -0.4±0.2 mg/dL, p=0.01；甘油三酯：-17.1±0.1 mg/dL vs -9.1±0.2 mg/dL, p=0.01；HbA1c: -1±0.1% vs. -0.3±0.2%,p=0.01)。在饮食干预后，只有非t等位基因携带者出现高甘油三酯血症、腹腰、高血糖和DM2的频率显著降低。结论：TCF7L2 （rs7903146）多态性调节pMR饮食诱导的体重、脂质代谢和胰岛素抵抗的变化。这些变化导致高血糖和代谢综合征的其他组成部分的患病率显著降低。
Effect of the Variant rs7903146 of Transcription Factor 7-Like 2 Gene on Anthropometric and Metabolic Responses to a 24 Weeks Meal Replacement Hypocaloric Diet.
Introduction: Some studies have demonstrated the effect of the rs7903146 genetic variant on weight response after different dietary strategies. The objective of our study was to evaluate the role of this genetic variant of the TCF7L2 gene on weight loss and diabetes mellitus progression following a partial meal replacement (pMR) hypocaloric diet.
Methods: We conducted an interventional study in 214 subjects with obesity and a body mass index (BMI) >35 kg/m2. The subjects received two servings per day of a normocaloric hyperproteic formula for 24 weeks as part of a pMR diet. Body weight, BMI, fat mass, waist circumference, lipid profile, fasting insulin levels, and HOMA-IR were determined. All patients were genotyped for rs7903146 and evaluated under a dominant model (CC vs. CT + TT).
Results: The decrease at 24 weeks was higher in non-T-allele carriers compared to T-allele carriers (BMI: -3.3 ± 0.3 kg/m2 vs. -2.2 ± 0.2 kg/m2; p = 0.02; weight: -9.5 ± 1.1 kg vs. -5.0 ± 1.0 kg; p = 0.01; fat mass: -8.7 ± 0.2 kg vs. -4.0 ± 0.2 kg; p = 0.04; waist circumference: -8.0 ± 0.2 cm vs. -3.0 ± 0.4 cm; p = 0.04; glucose levels: -7.1 ± 1.2 mg/dL vs. -1.2 ± 1.1 mg/dL; p = 0.01; insulin: -10.1 ± 1.1 µIU/L vs. -4.0 ± 1.0 µIU/L; p = 0.01; HOMA-IR: -2.1 ± 1.1 units vs. -0.5 ± 0.1 units; p = 0.01; C-reactive protein: -0.9 ± 0.1 mg/dL vs. -0.4 ± 0.2 mg/dL; p = 0.01; triglycerides: -17.1 ± 0.1 mg/dL vs. -9.1 ± 0.2 mg/dL; p = 0.01; and HbA1c: -1 ± 0.1% vs. -0.3 ± 0.2%; p = 0.01). Following the dietary intervention, only non-T-allele carriers showed a significant decrease in the frequency of hypertriglyceridemia, abdominal waist, hyperglycemia, and DM2.
Conclusions: The TCF7L2 (rs7903146) polymorphism modulates pMR diet-induced changes in body weight, lipid metabolism, and insulin resistance. These changes lead to a significant decrease in the prevalence of hyperglycemia and other components of metabolic syndrome.
期刊介绍：
''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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