其他健康儿童的长时间热性惊厥和长期神经系统后遗症。

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2025-01-27 DOI:10.1002/ana.27192

Takenori Suga MD, Takeshi Yoshida MD, PhD, Atsushi Yokoyama MD, PhD, Yotaro Hanami MD, Kazushige Ashina MD, Natsumi Nakamura MD, Koji Kawakami MD, PhD, Junko Takita MD, PhD, Masato Takeuchi MD, MPH, PhD

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引用次数: 0

摘要

在其他健康儿童中，长时间热性惊厥与长期神经系统后遗症之间的关系尚不清楚。我们使用日本全国医学数据库进行了回顾性队列研究。在38,465例发热性惊厥患儿队列中，分别有610例和31,157例被分为延长组和非延长组。在平均2.70年的随访中，长时间热性惊厥组继发癫痫的风险明显更高(风险比，3.99；95%置信区间为2.40-6.64)。两组发生神经发育障碍的风险相似(风险比，1.39；95%置信区间，1.00-1.79)。Ann neurol 2025。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prolonged Febrile Seizure and Long-Term Neurological Sequelae in Otherwise Healthy Children

The association between prolonged febrile seizure and long-term neurological sequelae in otherwise healthy children remains unclear. We conducted a retrospective cohort study using a Japanese nationwide medical database. In the cohort of 38,465 children with febrile seizures, 610 and 31,157 were classified into the prolonged and non-prolonged groups, respectively. Within a median of 2.70 years of follow-up, the risk of subsequent epilepsy was significantly higher in the prolonged febrile seizure group (hazard ratio, 3.99; 95% confidence interval, 2.40–6.64). The risk of neurodevelopmental disorders was similar between the two groups (hazard ratio, 1.39; 95% confidence interval, 1.00–1.79). ANN NEUROL 2025;97:688–693

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.