mRNA疫苗:释放潜力,探索应用,展望未来。

Gaurav Mishra, Sunny Rathee, Munish Garg, Umesh K Patil
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引用次数: 0

摘要

近年来,在开发mRNA疫苗方面取得了显著进展,从而产生了针对多种疾病的有效免疫。本文审查了这一领域的最新进展,重点讨论了它们对未来疫苗开发的影响。通过佐剂选择、递送系统优化和抗原选择的尖端方法,研究了提高疫苗效力的追求。这篇综述还探讨了基于基因图谱的个性化疫苗的潜力,以及确保疫苗稳定性和延长保质期的最新技术。该综述强调了mRNA疫苗在应对新发传染病及其变异方面的多功能性,强调了快速反应计划和先进技术对抗不断演变的病毒突变的重要性。总之,这一深入分析强调mRNA疫苗如何在重塑治疗和预防策略方面具有变革性潜力。值得注意的成就包括创建了针对SARS-CoV-2病毒的极其有效的mRNA疫苗,导致了COVID-19大流行。还讨论了为解决长期免疫保护和提高mRNA疫苗的有效性和稳定性等挑战而正在进行的努力。本综述的主要目的是全面总结mRNA疫苗技术的当前进展,同时探讨这些进展如何影响未来治疗和预防不同疾病的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
mRNA Vaccines: Unlocking Potential, Exploring Applications, and Envisioning Future Horizons.

In recent years, there have been notable strides in developing mRNA vaccines, resulting in the creation of potent immunizations against diverse diseases. This review examines the most recent advancements in this field, focusing on their implications for future vaccine development. The pursuit of heightened vaccine efficacy is investigated through cutting-edge methods in adjuvant selection, delivery system optimization, and antigen selection. The review also explores the potential for personalized vaccines based on genetic profiles, along with the latest techniques to ensure vaccine stability and extend shelf life. Highlighting the versatility of mRNA vaccines in addressing emerging infectious diseases and their variations, the review underscores the significance of swift response plans and advanced technologies to counter evolving viral mutations. In summary, this in-depth analysis emphasizes how mRNA vaccines hold transformative potential in reshaping both therapeutic and preventive strategies. Notable achievements include the creation of extremely potent mRNA vaccinations against the SARS-CoV-2 virus, resulting in the COVID-19 pandemic. Ongoing efforts to address challenges like long-term immune protection and increase the effectiveness and stability of mRNA vaccines are also discussed. This review's main goal is to provide a thorough summary of current advancements in mRNA vaccine technology while exploring how these advances may impact future approaches to treating and preventing different diseases.

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