[The relationship of constitutional-exogenous obesity and hormonalmicroelement status in adolescent boys with delayed sexual development].

Background: Childhood obesity and the rate of its spread is a serious threat to the reproductive health of the nation, especially among boys, being a background for delaying sexual development and further disrupting fertility.

Aim: To study the peculiarities of the ratio of the level of leptin and a number of toxic and essential chemical trace elements in biological environments in adolescent boys aged 13-14 years with obesity and delayed sexual development.

Materials and methods: Three groups of adolescents aged 13-14 years were studied and formed: the main ones - with constitutional exogenous obesity of 1-2 degrees (1-20 boys without secondary signs of puberty; 2 - 24 boys with 2-4 stages of puberty according to Tanner) and comparisons (3 - 15 boys with normal body weight and without deviations in puberty). The level of lead, zinc, selenium, chromium and manganese in the morning urine was determined by the absorption method; in the blood serum - leptin, by the method of enzyme immunoassay. Statistical analysis of the data was carried out in the MeoCape 11.4.2 Statistica environment, nonparametric Spearman correlation analysis and calculation of the Student's t-test for independent samples, the reliability of the results at p< 0.05.

Results: It was found that adolescents with obesity are characterized by a certain shift in the content of toxic and essential trace elements, the vector of which is shifted towards the predominance of levels of toxic chemical elements, in particular, ead, and a decrease in essential toxic elements, such as zinc, selenium, chromium and manganese. However, a more pronounced shift in the values in the imbalance of trace elements already violates not only the metabolic processes in the body of adolescent children, but also leads to a violation of puberty - to a delay in sexual development.

Conclusion: In the body of adolescent boys with obesity and delayed sexual development, the processes of oxidative stress, tissue hypoxia are progressing against the background of excess leptin, accumulation of heavy metals and deficiency of essential trace elements. Less pronounced shifts in the content of leptin and trace elements in adolescent boys are determined by a failure in neuroendocrine regulation, but does not affect the level of puberty. The homeostasis of the hormonal-microelement composition ensures the harmonious development of adolescent boys.