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IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-01-01 DOI:10.12669/pjms.41.1.10423

Rashida Parveen, Hajra Sultana, Sadia Nazir

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引用次数: 0

摘要

摘要确定孕产妇败血症的风险因素和结果：这项病例对照研究于 2023 年 6 月至 2024 年 5 月在巴基斯坦木尔坦市 Nishtar 医院和 Dera Ghazi Khan 市 Ghazi Khan 医院的妇产科进行。病例包括在研究期间被诊断患有产妇败血症的 18-45 岁女性。对照组为随机抽取的在研究期间报到并分娩的女性。败血症以血培养阳性报告为依据。报告了孕产妇败血症的各种风险因素以及孕产妇和胎儿结局的粗略赔率和调整赔率，以及 95% 的置信区间：共有 74 名产妇（每组 37 人），平均年龄（30.64±5.12）岁，平均孕周（36.19±1.84）周。多变量二元逻辑回归显示，孕龄低于 37 周（AOR：5.22；95% CI：1.35-19.67；P=0.015）、未预约病例（AOR：5.34；95% CI：1.19-24.2；P=0.029）和贫血（AOR：8.13；95% CI：1.05-63.10；P=0.045）是孕产妇败血症的重要预测因素。大肠杆菌是病例中最常见的病原体，影响了 14 例（37.8%）病例。患败血症的产妇死亡率明显高于未患败血症的产妇（32.4% 对 2.7%，P=0.008）：结论：孕龄低于 37 周、未进行产前预约和贫血是孕产妇败血症的重要预测因素。大肠杆菌是最常见的病原体。孕产妇败血症的高死亡率凸显了早期识别、有效管理和密切监测以降低孕产妇败血症死亡率的必要性。

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Maternal Sepsis and associated factors: A multi-central study from two tertiary care hospitals of South Punjab, Pakistan.

Objective: To determine the risk factors and outcomes of maternal sepsis.

Methods: This case-control study was performed at the departments of Obstetrics & Gynecology, Nishtar Hospital, Multan, and Ghazi Khan Hospital, Dera Ghazi Khan, Pakistan, from June 2023 to May 2024. Cases were comprised of females aged 18-45 years diagnosed with maternal sepsis, and admitted during the study period. Controls were randomly selected females reporting during the study period and undergoing delivery. Sepsis was labeled on the basis of positive blood culture report. Crude and adjusted odds ratio with 95% confidence interval were reported regarding various risk factors of maternal sepsis as well as maternal and fetal outcomes taking p<0.05 as significant. Mortality was noted from the onset of labor until seven days postpartum.

Results: In a total of 74 women (37 in each group), the mean age and, gestational age were 30.64±5.12 years, and 36.19±1.84 weeks, respectively. Multivariate binary logistic regression showed that gestational age below 37 weeks (AOR: 5.22; 95% CI: 1.35-19.67; p=0.015), unbooked cases (AOR: 5.34; 95% CI: 1.19-24.2; p=0.029), and anemia (AOR: 8.13; 95% CI: 1.05-63.10; p=0.045) were significant predictors of maternal sepsis. E. coli was the most common etiological agent among cases, affecting 14 (37.8%) cases. Mortality was significantly high among females with maternal sepsis versus those without maternal sepsis (32.4% vs. 2.7%, p=0.008).

Conclusion: Gestational age below 37 weeks, lack of antenatal booking, and anemia were found to be significant predictors of maternal sepsis. E. coli was the most common pathogen identified. High mortality rate in maternal sepsis highlights the need for early identification, effective management, and close monitoring to reduce maternal mortality from sepsis.

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.