5-羟曲坦胺对大鼠精子过度活化及体外生育能力的影响。

IF 1.9 4区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Reproduction and Development Pub Date : 2025-04-14 Epub Date: 2025-01-25 DOI:10.1262/jrd.2024-078

Yuki Koyano, Masakatsu Fujinoki

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引用次数: 0

摘要

神经递质5-羟雷公胺（5-HT）是众所周知的。此外，它还能增强仓鼠和小鼠的顶体反应、过度活化和体外受精（IVF）的成功。在本研究中，我们研究了5-HT是否会增强大鼠的过度激活并增加体外受精成功率。当大鼠精子暴露于5-HT时，超激活明显增强。只有5-HT4受体激动剂显著增强了过度活化。此外，5-HT和5-HT4受体激动剂均可显著提高体外受精成功率。这些结果表明，5-HT通过增强超激活而提高体外受精成功率，其作用与5-HT4受体有关。因此，在大鼠中，5-羟色胺增强了获能，而5-HT4受体是获能的关键分子。

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Influences of 5-hydroxytriptamine on sperm hyperactivation and in vitro fertility in rats.

The neurotransmitter, 5-hydroxytriptamine (5-HT), is well known. Furthermore, it enhances the acrosome reaction, hyperactivation, and in vitro fertilization (IVF) success in hamsters and mice. In the present study, we examined whether 5-HT enhances hyperactivation and increases IVF success in rats. When rat sperm was exposed to 5-HT, hyperactivation was significantly enhanced. Only the 5-HT₄ receptor agonists significantly enhanced hyperactivation. Additionally, both 5-HT and 5-HT₄ receptor agonists significantly increase the success of IVF. These results suggested that 5-HT increases IVF success by enhancing hyperactivation and effects of 5-HT are associated with the 5-HT₄ receptor. Therefore, in rats, 5-HT enhances capacitation and the 5-HT₄ receptor is the key molecule for capacitation.

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来源期刊

Journal of Reproduction and Development 生物-奶制品与动物科学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

2 months

期刊介绍： Journal of Reproduction and Development (JRD) is the official journal of the Society for Reproduction and Development, published bimonthly, and welcomes original articles. JRD provides free full-text access of all the published articles on the web. The functions of the journal are managed by Editorial Board Members, such as the Editor-in-Chief, Co-Editor-inChief, Managing Editors and Editors. All manuscripts are peer-reviewed critically by two or more reviewers. Acceptance is based on scientific content and presentation of the materials. The Editors select reviewers and correspond with authors. Final decisions about acceptance or rejection of manuscripts are made by the Editor-in-Chief and Co-Editor-in-Chief.