子宫内膜异位症患者冷冻胚胎移植优于新鲜胚胎移植的生殖结局:一项历史队列研究。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
International Journal of Reproductive Biomedicine Pub Date : 2024-01-10 eCollection Date: 2024-11-01 DOI:10.18502/ijrm.v22i11.17819
Parisa Pirooznia, Mehri Mashayekhi, Firouzeh Ghaffari, Nadia Jahangiri, Zahra Zolfaghari, Firoozeh Ahmadi, Fateme Hasani, Nima Narimani
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引用次数: 0

摘要

背景:子宫内膜异位症是子宫内膜异位症的一种常见表现,通常表明该疾病的严重程度。体外受精和胚胎移植(ET)是治疗子宫内膜异位症不孕的关键策略。然而,最佳的体外受精类型(冷冻或新鲜)及其对怀孕成功率的影响仍然存在争议,可用的研究有限。目的:本历史队列研究旨在比较新鲜胚胎移植和冷冻胚胎移植(FET)对子宫内膜异位症相关不孕患者的生育和新生儿结局,重点关注活产率(LBR)、临床妊娠和着床率。材料和方法:在这项历史队列研究中,回顾了2016年3月至2021年3月在伊朗德黑兰Royan研究所接受体外受精/卵胞浆内单精子注射治疗的289名诊断为子宫内膜异位症相关不孕症的妇女的医疗记录(文件)。最终,选择了200个符合既定标准的文件进行审查。然后将提取的数据在两组之间进行比较:FET (n = 121)和fresh ET (n = 79)。结果:两组在人口统计学特征和子宫内膜瘤大小方面无显著差异。生育结果的唯一显著差异是LBR, FET组为36.4%,而新鲜ET组为22.8% (p = 0.04)。两组新生儿结局无显著差异。总的来说,我们的研究表明FET可能导致诊断为子宫内膜异位瘤的女性更高的lbr。结论:我们的研究表明FET可能导致诊断为子宫内膜异位瘤的女性更高的lbr。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving reproductive outcomes in frozen embryo transfer over fresh embryo transfer in women with endometrioma: A historical cohort study.

Background: Endometrioma, a common manifestation of endometriosis, often indicates the severity of the disease. In vitro fertilization and embryo transfer (ET) are key therapeutic strategies for infertility associated with endometriosis. However, the optimal type of ET (frozen or fresh) and its impact on pregnancy success rates remain debated, with limited studies available.

Objective: This historical cohort study aimed to compare fertility and neonatal outcomes, focusing on live birth rate (LBR), clinical pregnancy, and implantation rates in women with endometrioma-associated infertility, between fresh and frozen embryo transfer (FET).

Materials and methods: In this historical cohort study, the medical records (files) of 289 women diagnosed with endometrioma-related infertility, who underwent in vitro fertilization/intracytoplasmic sperm injection treatment at Royan Institute, Tehran, Iran between March 2016-2021 were reviewed. Ultimately, 200 files that met the established criteria were selected for review. The extracted data was then compared between groups: FET (n = 121) and fresh ET (n = 79).

Results: No significant differences were observed between the groups in terms of demographic characteristics and endometrioma size. The only significant difference in fertility outcomes was the LBR, which was 36.4% for the FET group compared to 22.8% for the fresh ET group (p = 0.04). No significant differences were observed in neonatal outcomes between the groups. Overall, our study suggests that FET may lead to higher LBRs in women diagnosed with endometrioma.

Conclusion: Our study suggests that FET may lead to higher LBRs in women diagnosed with endometrioma.

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来源期刊
CiteScore
2.40
自引率
7.70%
发文量
93
审稿时长
16 weeks
期刊介绍: The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.
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