Andreas Pekey, Leonard Nainggolan, Cosphiadi Irawan, Kuntjoro Harimurti
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引用次数: 0
摘要
背景：疟疾感染已造成显著的发病率和死亡率，特别是在高危人群中。一些证据表明，ABO血型可能与疟疾的严重程度有关。本研究旨在确定血型与巴布亚疟疾严重程度之间的关系，因为巴布亚是疟疾流行地区。方法：在印度尼西亚查亚普拉的一家地区转诊医院进行横断面研究。疟疾的诊断是根据世界卫生组织的标准确定的，并分为严重疟疾和无并发症疟疾。血型分为O型血和非O型血。结果：210例患者中，非O型血84例（40%），O型血126例（60%）。与O型血相比，非O型血的严重疟疾患病率更高(16.7%比9.5%；患病率（PR）为2.4；95% ci 1.06-6.42；P值0.032)。在非o型人群中，B型人群重症疟疾发病率最高(p值0.038；95% ci: 1.06-6.42)。结论：在巴布亚，ABO血型与疟疾的严重程度有关。严重疟疾多发生在非o型血，尤其是B型血。
Association Between ABO Blood Groups and Malaria Severity in a Regional Referral Hospital in Jayapura Papua, Indonesia.
Background: Malaria infection has caused a significant morbidity and mortality, notably in high-risk groups. Some evidence showed that ABO blood types might associate with malaria severity. This study aimed to determine the relationship between blood types and malaria severity in Papua, as Papua is a malaria-endemic area.
Methods: A cross-sectional study was conducted in a regional referral hospital in Jayapura, Indonesia. Diagnosis of malaria was determined using World Health Organization criteria and classified into severe and uncomplicated malaria. Blood types were classified into O and non-O groups.
Results: Out of 210 patients, 84 (40%) and 126 (60%) patients had non-O and O blood types, respectively. Severe malaria was more prevalent in non-O compared to O blood type (16.7% vs. 9.5%; the prevalence ratio (PR) was 2.4; 95% CI 1.06-6.42; p value 0.032). Amongst non-O groups, group B blood type demonstrated the highest incidence of severe malaria (p value 0.038; 95% CI: 1.06-6.42).
Conclusion: There is an association between ABO blood group and the severity of malaria in Papua. Severe malaria was found more in non-O blood types, especially type B blood group.
期刊介绍：
Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine is an open accessed online journal and comprehensive peer-reviewed medical journal published by the Indonesian Society of Internal Medicine since 1968. Our main mission is to encourage the novel and important science in the clinical area in internal medicine. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of internal medicine. Subjects suitable for publication include, but are not limited to the following fields of: -Allergy and immunology -Emergency medicine -Cancer and stem cells -Cardiovascular -Endocrinology and Metabolism -Gastroenterology -Gerontology -Hematology -Hepatology -Tropical and Infectious Disease -Virology -Internal medicine -Psychosomatic -Pulmonology -Rheumatology -Renal and Hypertension -Thyroid
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