{"title":"Lanostane Triterpenes, Flavanones and Acetogenins from the Roots of <i>Uvaria siamensis</i> and Their Cytotoxic Activity.","authors":"Lueacha Tabtimmai, Kiattawee Choowongkomon, Prasat Kittakoop, Ratsami Lekphrom, Florian Thierry Schevenels, Supachai Jadsadajerm, Awat Wisetsai","doi":"10.1021/acsomega.4c09267","DOIUrl":null,"url":null,"abstract":"<p><p>Our phytochemical investigation of the roots of <i>Uvaria siamensis</i> led to the isolation of two new lanostane triterpenes, 3-acetylpolycarpol (<b>1</b>) and 15-acetylpolycarpol (<b>2</b>), as well as 15 known compounds (<b>3</b>-<b>17</b>). The structures of the isolated compounds were elucidated by an analysis of spectroscopic data. Compounds <b>1</b>-<b>9</b> were tested against nonsmall cell lung cancer cells (A549) and human cervical carcinoma cells (HeLa) using an MTT assay. Polycarpol (<b>3</b>) and uvariamicin-II (<b>9</b>) exhibited potent cytotoxicity against A549 cancer cells, while 15-acetylpolycarpol (<b>2</b>) and pinocembrin (<b>4</b>) displayed potent cytotoxicity against HeLa cancer cells. Further analysis of the apoptosis-inducing properties revealed that uvariamicin-II (<b>9</b>) and pinocembrin (<b>4</b>) induced apoptosis in a dose-dependent manner in A549 and HeLa cells, respectively. These two compounds also showed weak cytotoxicity toward <i>Vero</i> cells.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2253-2259"},"PeriodicalIF":3.7000,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755176/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Omega","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acsomega.4c09267","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/21 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
通过对暹罗乌蔹莓根部的植物化学研究，我们分离出了两种新的羊角甾三萜类化合物：3-乙酰基聚carpol（1）和 15-乙酰基聚carpol（2），以及 15 种已知化合物（3-17）。通过分析光谱数据，阐明了分离出的化合物的结构。利用 MTT 法测试了 1-9 化合物对非小细胞肺癌细胞（A549）和人类宫颈癌细胞（HeLa）的作用。Polycarpol (3) 和 uvariamicin-II (9) 对 A549 癌细胞显示出了强大的细胞毒性，而 15-acetylpolycarpol (2) 和 pinocembrin (4) 则对 HeLa 癌细胞显示出了强大的细胞毒性。对凋亡诱导特性的进一步分析表明，乌伐霉素-II（9）和松果菊素（4）分别以剂量依赖的方式诱导 A549 和 HeLa 细胞凋亡。这两种化合物对 Vero 细胞也有微弱的细胞毒性。
Lanostane Triterpenes, Flavanones and Acetogenins from the Roots of Uvaria siamensis and Their Cytotoxic Activity.
Our phytochemical investigation of the roots of Uvaria siamensis led to the isolation of two new lanostane triterpenes, 3-acetylpolycarpol (1) and 15-acetylpolycarpol (2), as well as 15 known compounds (3-17). The structures of the isolated compounds were elucidated by an analysis of spectroscopic data. Compounds 1-9 were tested against nonsmall cell lung cancer cells (A549) and human cervical carcinoma cells (HeLa) using an MTT assay. Polycarpol (3) and uvariamicin-II (9) exhibited potent cytotoxicity against A549 cancer cells, while 15-acetylpolycarpol (2) and pinocembrin (4) displayed potent cytotoxicity against HeLa cancer cells. Further analysis of the apoptosis-inducing properties revealed that uvariamicin-II (9) and pinocembrin (4) induced apoptosis in a dose-dependent manner in A549 and HeLa cells, respectively. These two compounds also showed weak cytotoxicity toward Vero cells.
ACS OmegaChemical Engineering-General Chemical Engineering
CiteScore
6.60
自引率
4.90%
发文量
3945
审稿时长
2.4 months
期刊介绍：
ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.
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