中性粒细胞和嘌呤能信号：对抗利什曼原虫的合作伙伴？

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimie Pub Date : 2025-01-23 DOI:10.1016/j.biochi.2025.01.004

Mariana M. Chaves

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引用次数: 0

摘要

利什曼原虫属的寄生虫是影响人类的疾病利什曼病的病原体。这些疾病影响全世界数百万人，目前的药物要么毒性很大，要么寄生虫获得耐药性。因此，需要阐明新的消除机制，以便开发新的治疗策略。关于中性粒细胞在利什曼原虫感染中的作用已经讨论了很多，它们的参与仍然存在争议。最近的一项研究表明，中性粒细胞膜上存在的受体嘌呤能受体在被激活时可以控制感染，但其触发机制尚未阐明。在这篇综述中，我们将讨论中性粒细胞胞外膜表达的嘌呤能受体可能参与利什曼原虫感染的检测及其在寄生过程中的可能作用。

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Neutrophils and purinergic signaling: Partners in the crime against Leishmania parasites?

The parasite of the genus Leishmania is the causative agent of diseases that affect humans called leishmaniasis. These diseases affect millions of people worldwide and the currently existing drugs are either very toxic or the parasites acquire resistance. Therefore, new elimination mechanisms need to be elucidated so that new therapeutic strategies can be developed. Much has already been discussed about the role of neutrophils in Leishmania infection, and their participation is still controversial. A recent study showed that receptors present in the neutrophil membrane, the purinergic receptors, can control the infection when activated, but the triggering mechanism has not been elucidated. In this review, we will address the possible participation of purinergic receptors expressed in the neutrophil extracellular membrane that may be participating in the detection of Leishmania infection and their possible effects during parasitism.

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.